ENSG00000132906


Homo sapiens

Features
Gene ID: ENSG00000132906
  
Biological name :CASP9
  
Synonyms : CASP9 / caspase 9 / P55211
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.21
Gene start: 15490832
Gene end: 15526534
  
Corresponding Affymetrix probe sets: 203984_s_at (Human Genome U133 Plus 2.0 Array)   210775_x_at (Human Genome U133 Plus 2.0 Array)   240437_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449584
Ensembl peptide - ENSP00000449216
Ensembl peptide - ENSP00000480785
Ensembl peptide - ENSP00000255256
Ensembl peptide - ENSP00000330237
Ensembl peptide - ENSP00000365051
Ensembl peptide - ENSP00000383588
Ensembl peptide - ENSP00000396540
Ensembl peptide - ENSP00000408691
Ensembl peptide - ENSP00000411304
NCBI entrez gene - 842     See in Manteia.
OMIM - 602234
RefSeq - XM_011542273
RefSeq - NM_001229
RefSeq - NM_001278054
RefSeq - NM_032996
RefSeq - XM_005246014
RefSeq Peptide - NP_127463
RefSeq Peptide - NP_001220
RefSeq Peptide - NP_001264983
swissprot - P55211
swissprot - F8VVS7
swissprot - F8VWA5
swissprot - H0Y3S8
swissprot - Q5JRU2
swissprot - H0Y6Y2
swissprot - Q5JRU8
swissprot - A0A087WX72
Ensembl - ENSG00000132906
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp9ENSDARG00000004325Danio rerio
 CASP9ENSGALG00000001366Gallus gallus
 Casp9ENSMUSG00000028914Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP2 / P42575 / caspase 2ENSG0000010614428
CASP8 / Q14790 / caspase 8ENSG0000006401226
CASP10 / Q92851 / caspase 10ENSG0000000340025
CASP7 / P55210 / caspase 7ENSG0000016580622
CASP3 / P42574 / caspase 3ENSG0000016430522
CASP6 / P55212 / caspase 6ENSG0000013879420
CASP14 / P31944 / caspase 14ENSG0000010514117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR033171  Caspase-9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c TAS
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030220 platelet formation TAS
 biological_processGO:0032025 response to cobalt ion IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034349 glial cell apoptotic process IEA
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0042770 signal transduction in response to DNA damage IDA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand TAS
 biological_processGO:0097194 execution phase of apoptosis IBA
 biological_processGO:2001020 regulation of response to DNA damage stimulus IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043293 apoptosome IDA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
NOD1/2 Signaling Pathway
AKT phosphorylates targets in the cytosol
via Dependence Receptors in the absence of ligand
Constitutive Signaling by AKT1 E17K in Cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157500 APPL1 / Q9UKG1 / adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1  / reaction / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / reaction / complex
 ENSG00000172115 CYCS / P99999 / cytochrome c, somatic  / reaction / complex
 ENSG00000120868 APAF1 / O14727 / apoptotic peptidase activating factor 1  / reaction / complex
 ENSG00000184047 DIABLO / Q9NR28 / diablo IAP-binding mitochondrial protein  / reaction / complex
 ENSG00000165806 CASP7 / P55210 / caspase 7  / reaction
 ENSG00000132906 CASP9 / P55211 / caspase 9  / complex
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000101966 XIAP / P98170 / X-linked inhibitor of apoptosis  / complex






 

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