ENSGALG00000001366


Gallus gallus

Features
Gene ID: ENSGALG00000001366
  
Biological name :CASP9
  
Synonyms : CASP9 / caspase 9
  
Possible biological names infered from orthology : Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211 / Q8C3Q9
  
Species: Gallus gallus
  
Chr. number: 21
Strand: 1
Band:
Gene start: 4917508
Gene end: 4923271
  
Corresponding Affymetrix probe sets: Gga.4116.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002083
NCBI entrez gene - 426970     See in Manteia.
RefSeq - XM_424580
swissprot - F1NL59
Ensembl - ENSGALG00000001366
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp9ENSDARG00000004325Danio rerio
 CASP9ENSG00000132906Homo sapiens
 Casp9ENSMUSG00000028914Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP2 / caspase-2 / P29594* / P42575* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSGALG0000001469826
CASP10 / caspase 10 / Q92851*ENSGALG0000004649424
CASP8 / caspase-8 / O89110* / Q14790* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSGALG0000000835524
CASP7 / caspase 7 / P55210* / P97864* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSGALG0000000893323
CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSGALG0000001063822
CASP18ENSGALG0000000834622
CASP6 / caspase-6 / O08738* / P55212* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSGALG0000001218621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001315  CARD domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR033171  Caspase-9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IDA
 biological_processGO:0070306 lens fiber cell differentiation IDA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 biological_processGO:2001020 regulation of response to DNA damage stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043293 apoptosome IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
NOD1/2 Signaling Pathway
AKT phosphorylates targets in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / reaction
 ENSGALG00000008933 CASP7 / caspase 7 / P55210* / P97864* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*  / reaction
 ENSGALG00000001366 CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*  / complex
 ENSGALG00000011020 CYCS / P67881 / Cytochrome c / P99999* / P62897* / Gm10053* / predicted gene 10053* / cytochrome c, somatic*  / reaction / complex
 ENSGALG00000011531 APAF1 / apoptotic peptidase activating factor 1 / O14727* / O88879* / Apoptotic protease-activating factor 1 *  / reaction / complex






 

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