ENSGALG00000008933


Gallus gallus

Features
Gene ID: ENSGALG00000008933
  
Biological name :CASP7
  
Synonyms : CASP7 / caspase 7
  
Possible biological names infered from orthology : Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210 / P97864
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 27520205
Gene end: 27538328
  
Corresponding Affymetrix probe sets: GgaAffx.5618.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014503
NCBI entrez gene - 423901     See in Manteia.
RefSeq - XM_421764
swissprot - F1NV61
Ensembl - ENSGALG00000008933
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp7ENSDARG00000091836Danio rerio
 CASP7ENSG00000165806Homo sapiens
 Casp7ENSMUSG00000025076Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSGALG0000001063849
CASP6 / caspase-6 / O08738* / P55212* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSGALG0000001218635
CASP8 / caspase-8 / O89110* / Q14790* / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10*ENSGALG0000000835534
CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSGALG0000000136632
CASP10 / caspase 10 / Q92851*ENSGALG0000004649430
CASP18ENSGALG0000000834629
CASP2 / caspase-2 / P29594* / P42575* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSGALG0000001469826


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0097194 execution phase of apoptosis IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Activation of caspases through apoptosome-mediated cleavage
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001366 CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000008933 CASP7 / caspase 7 / P55210* / P97864* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*  / complex
 ENSGALG00000004412 DIABLO* / Q9JIQ3* / Q9NR28* / Diablo homolog, mitochondrial * / diablo IAP-binding mitochondrial protein*  / reaction / complex
 ENSGALG00000008491 XIAP / BIRC8* / P98170* / Q60989* / Q96P09* / X-linked inhibitor of apoptosis* / baculoviral IAP repeat containing 8*  / complex
 ENSGALG00000016885 STK24 / serine/threonine kinase 24 / Q99KH8* / Q9Y6E0*  / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction
 ENSGALG00000003655 GAS2 / growth arrest specific 2 / O43903* / P11862* / Mus musculus growth arrest specific 2 (Gas2), transcript variant 2, mRNA.*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr