ENSGALG00000008491


Gallus gallus

Features
Gene ID: ENSGALG00000008491
  
Biological name :XIAP
  
Synonyms : XIAP
  
Possible biological names infered from orthology : baculoviral IAP repeat containing 8 / BIRC8 / P98170 / Q60989 / Q96P09 / X-linked inhibitor of apoptosis
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 15719928
Gene end: 15737277
  
Corresponding Affymetrix probe sets: Gga.104.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013821
NCBI entrez gene - 395280     See in Manteia.
RefSeq - XM_015278182
RefSeq - NM_204588
RefSeq - XM_015278183
RefSeq Peptide - NP_989919
swissprot - Q8UVF8
Ensembl - ENSGALG00000008491
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xiapENSDARG00000016143Danio rerio
 BIRC8ENSG00000163098Homo sapiens
 XIAPENSG00000101966Homo sapiens
 XiapENSMUSG00000025860Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BIRC2 / BIRC3* / Q62210* / Q13489* / Q13490* / baculoviral IAP repeat containing 2* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *ENSGALG0000001718640
BIRC7 / baculoviral IAP repeat containing 7 / A2AWP0* / Q96CA5* / Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30 kDa subunit*ENSGALG0000000576227


Protein motifs (from Interpro)
Interpro ID Name
 IPR001370  BIR repeat
 IPR001841  Zinc finger, RING-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IBA
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Deactivation of the beta-catenin transactivating complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004412 DIABLO* / Q9JIQ3* / Q9NR28* / Diablo homolog, mitochondrial * / diablo IAP-binding mitochondrial protein*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000008933 CASP7 / caspase 7 / P55210* / P97864* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*  / complex
 ENSGALG00000015184 TLE4Z1 / transducin like enhancer of split 4-Z 1 / TLE4* / Q62441* / Q04727* / transducin like enhancer of split 4* / Transducin-like enhancer protein 4 *  / reaction / complex
 ENSGALG00000012575 TLE1 / transducin like enhancer of split 1 / Q04724* / Q62440* / Transducin-like enhancer protein 1 *  / reaction / complex






 

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