ENSGALG00000008355


Gallus gallus

Features
Gene ID: ENSGALG00000008355
  
Biological name :CASP8
  
Synonyms : CASP8 / caspase-8
  
Possible biological names infered from orthology : Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / O89110 / Q14790
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 11502439
Gene end: 11508768
  
Corresponding Affymetrix probe sets: Gga.2451.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053474
Ensembl peptide - ENSGALP00000013591
NCBI entrez gene - 395284     See in Manteia.
RefSeq - XM_015289376
RefSeq - NM_204592
RefSeq - XM_015289374
RefSeq - XM_015289375
RefSeq Peptide - NP_989923
swissprot - F1NXP6
swissprot - A0A1D5PKW1
Ensembl - ENSGALG00000008355
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp8ENSDARG00000058325Danio rerio
 CASP8ENSG00000064012Homo sapiens
 Casp8ENSMUSG00000026029Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP18ENSGALG0000000834649
CASP10 / caspase 10 / Q92851*ENSGALG0000004649439
CASP7 / caspase 7 / P55210* / P97864* / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11*ENSGALG0000000893322
CASP9 / caspase 9 / P55211* / Q8C3Q9* / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.*ENSGALG0000000136621
CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*ENSGALG0000001063820
CASP2 / caspase-2 / P29594* / P42575* / Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12*ENSGALG0000001469820
CASP6 / caspase-6 / O08738* / P55212* / Caspase-6 Caspase-6 subunit p18 Caspase-6 subunit p11*ENSGALG0000001218620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site
 IPR033170  Caspase-8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IBA
 biological_processGO:0030225 macrophage differentiation IBA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
CASP8 activity is inhibited
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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