ENSG00000165806


Homo sapiens

Features
Gene ID: ENSG00000165806
  
Biological name :CASP7
  
Synonyms : CASP7 / caspase 7 / P55210
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q25.3
Gene start: 113679162
Gene end: 113730907
  
Corresponding Affymetrix probe sets: 207181_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478999
Ensembl peptide - ENSP00000478285
Ensembl peptide - ENSP00000480584
Ensembl peptide - ENSP00000298701
Ensembl peptide - ENSP00000358321
Ensembl peptide - ENSP00000358324
Ensembl peptide - ENSP00000358327
Ensembl peptide - ENSP00000358337
Ensembl peptide - ENSP00000398107
Ensembl peptide - ENSP00000400094
NCBI entrez gene - 840     See in Manteia.
OMIM - 601761
RefSeq - XM_017016764
RefSeq - NM_001227
RefSeq - NM_001267056
RefSeq - NM_001267057
RefSeq - NM_001267058
RefSeq - NM_001320911
RefSeq - NM_033338
RefSeq - NM_033339
RefSeq - NM_033340
RefSeq - XM_006718017
RefSeq - XM_011540260
RefSeq - XM_017016763
RefSeq Peptide - NP_001253987
RefSeq Peptide - NP_001307840
RefSeq Peptide - NP_203124
RefSeq Peptide - NP_203125
RefSeq Peptide - NP_203126
RefSeq Peptide - NP_001218
RefSeq Peptide - NP_001253985
RefSeq Peptide - NP_001253986
swissprot - P55210
swissprot - Q5SVL2
swissprot - A0A0A0MRL7
Ensembl - ENSG00000165806
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casp7ENSDARG00000091836Danio rerio
 CASP7ENSGALG00000008933Gallus gallus
 Casp7ENSMUSG00000025076Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CASP3 / P42574 / caspase 3ENSG0000016430537
CASP8 / Q14790 / caspase 8ENSG0000006401227
CASP10 / Q92851 / caspase 10ENSG0000000340026
CASP6 / P55212 / caspase 6ENSG0000013879426
CASP9 / P55211 / caspase 9ENSG0000013290624
CASP2 / P42575 / caspase 2ENSG0000010614421
CASP14 / P31944 / caspase 14ENSG0000010514118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR002138  Peptidase C14, caspase non-catalytic subunit p10
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR016129  Peptidase family C14A, His active site
 IPR029030  Caspase-like domain superfamily
 IPR033139  Peptidase family C14A, cysteine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c TAS
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0072734 cellular response to staurosporine IMP
 biological_processGO:0097194 execution phase of apoptosis TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008234 cysteine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP


Pathways (from Reactome)
Pathway description
Activation of caspases through apoptosome-mediated cleavage
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184047 DIABLO / Q9NR28 / diablo IAP-binding mitochondrial protein  / reaction / complex
 ENSG00000132906 CASP9 / P55211 / caspase 9  / reaction
 ENSG00000165806 CASP7 / P55210 / caspase 7  / complex
 ENSG00000026025 VIM / P08670 / vimentin  / reaction
 ENSG00000101966 XIAP / P98170 / X-linked inhibitor of apoptosis  / complex
 ENSG00000102572 STK24 / Q9Y6E0 / serine/threonine kinase 24  / reaction
 ENSG00000148935 GAS2 / O43903 / growth arrest specific 2  / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction
 ENSG00000092853 CLSPN / Q9HAW4 / claspin  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr