ENSG00000169398


Homo sapiens

Features
Gene ID: ENSG00000169398
  
Biological name :PTK2
  
Synonyms : protein tyrosine kinase 2 / PTK2 / Q05397
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.3
Gene start: 140657900
Gene end: 141002216
  
Corresponding Affymetrix probe sets: 1559529_at (Human Genome U133 Plus 2.0 Array)   207821_s_at (Human Genome U133 Plus 2.0 Array)   208820_at (Human Genome U133 Plus 2.0 Array)   241387_at (Human Genome U133 Plus 2.0 Array)   241453_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428593
Ensembl peptide - ENSP00000428570
Ensembl peptide - ENSP00000428792
Ensembl peptide - ENSP00000431106
Ensembl peptide - ENSP00000431023
Ensembl peptide - ENSP00000430951
Ensembl peptide - ENSP00000430916
Ensembl peptide - ENSP00000430828
Ensembl peptide - ENSP00000430603
Ensembl peptide - ENSP00000430277
Ensembl peptide - ENSP00000430044
Ensembl peptide - ENSP00000430037
Ensembl peptide - ENSP00000429958
Ensembl peptide - ENSP00000429929
Ensembl peptide - ENSP00000429911
Ensembl peptide - ENSP00000429907
Ensembl peptide - ENSP00000429895
Ensembl peptide - ENSP00000429702
Ensembl peptide - ENSP00000429530
Ensembl peptide - ENSP00000429474
Ensembl peptide - ENSP00000429437
Ensembl peptide - ENSP00000429409
Ensembl peptide - ENSP00000429170
Ensembl peptide - ENSP00000429129
Ensembl peptide - ENSP00000429082
Ensembl peptide - ENSP00000429028
Ensembl peptide - ENSP00000429023
Ensembl peptide - ENSP00000429001
Ensembl peptide - ENSP00000341189
Ensembl peptide - ENSP00000378644
Ensembl peptide - ENSP00000403416
Ensembl peptide - ENSP00000427762
Ensembl peptide - ENSP00000427774
Ensembl peptide - ENSP00000427795
Ensembl peptide - ENSP00000427825
Ensembl peptide - ENSP00000427904
Ensembl peptide - ENSP00000427972
Ensembl peptide - ENSP00000428232
Ensembl peptide - ENSP00000428380
Ensembl peptide - ENSP00000428482
Ensembl peptide - ENSP00000428492
NCBI entrez gene - 5747     See in Manteia.
OMIM - 600758
RefSeq - XM_017013690
RefSeq - NM_153831
RefSeq - XM_005251003
RefSeq - XM_005251012
RefSeq - XM_005251013
RefSeq - XM_006716608
RefSeq - XM_006716609
RefSeq - XM_006716610
RefSeq - XM_011517194
RefSeq - XM_017013651
RefSeq - XM_017013652
RefSeq - XM_017013653
RefSeq - XM_017013654
RefSeq - XM_017013655
RefSeq - XM_017013656
RefSeq - XM_017013657
RefSeq - XM_017013658
RefSeq - XM_017013659
RefSeq - XM_017013660
RefSeq - XM_017013661
RefSeq - XM_017013662
RefSeq - XM_017013663
RefSeq - XM_017013664
RefSeq - XM_017013665
RefSeq - XM_017013666
RefSeq - XM_017013667
RefSeq - XM_017013668
RefSeq - XM_017013669
RefSeq - XM_017013670
RefSeq - XM_017013671
RefSeq - XM_017013672
RefSeq - XM_017013673
RefSeq - XM_017013674
RefSeq - XM_017013675
RefSeq - XM_017013676
RefSeq - XM_017013677
RefSeq - XM_017013678
RefSeq - XM_017013679
RefSeq - XM_017013680
RefSeq - XM_017013681
RefSeq - XM_017013682
RefSeq - XM_017013683
RefSeq - XM_017013684
RefSeq - XM_017013685
RefSeq - XM_017013686
RefSeq - XM_017013687
RefSeq - XM_017013688
RefSeq - XM_017013689
RefSeq - NM_001199649
RefSeq - NM_001316342
RefSeq - NM_001352696
RefSeq - NM_001352709
RefSeq - NM_001352714
RefSeq - NM_001352717
RefSeq - NM_001352718
RefSeq - NM_001352738
RefSeq - NM_001352739
RefSeq - NM_001352740
RefSeq - NM_001352741
RefSeq - NM_005607
RefSeq Peptide - NP_001339643
RefSeq Peptide - NP_001339646
RefSeq Peptide - NP_001339647
RefSeq Peptide - NP_001339667
RefSeq Peptide - NP_001339668
RefSeq Peptide - NP_001339669
RefSeq Peptide - NP_001339670
RefSeq Peptide - NP_005598
RefSeq Peptide - NP_722560
RefSeq Peptide - NP_001339625
RefSeq Peptide - NP_001339638
RefSeq Peptide - NP_001186578
RefSeq Peptide - NP_001303271
RefSeq Peptide - NP_001339623
swissprot - E5RH48
swissprot - E5RH08
swissprot - E5RH01
swissprot - E5RGP1
swissprot - E5RGA6
swissprot - E5RG86
swissprot - E5RG80
swissprot - E5RG66
swissprot - E5RG54
swissprot - E5RFW9
swissprot - B4DWJ1
swissprot - H0YAS0
swissprot - H0YB16
swissprot - H0YB33
swissprot - E9PEI4
swissprot - H0YBP1
swissprot - H0YBZ1
swissprot - Q05397
swissprot - A0A1D5RMT1
swissprot - H0YB99
swissprot - E7ESA6
swissprot - E5RJQ2
swissprot - E5RJP0
swissprot - E5RJN1
swissprot - E5RJI4
swissprot - E5RIR5
swissprot - E5RIK4
swissprot - E5RII9
swissprot - E5RI72
swissprot - E5RI29
swissprot - E5RI03
swissprot - E5RHK7
swissprot - E5RHD8
Ensembl - ENSG00000169398
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptk2aaENSDARG00000100456Danio rerio
 ptk2abENSDARG00000004672Danio rerio
 PTK2ENSGALG00000031741Gallus gallus
 Ptk2ENSMUSG00000022607Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTK2B / Q14289 / protein tyrosine kinase 2 betaENSG0000012089944
ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2ENSG0000014173619
ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4ENSG0000017856819
EGFR / P00533 / epidermal growth factor receptorENSG0000014664818
ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3ENSG0000006536116
TNK2 / Q07912 / tyrosine kinase non receptor 2ENSG0000006193816
TNK1 / Q13470 / tyrosine kinase non receptor 1ENSG0000017429214
ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70ENSG0000011508514
SYK / P43405 / spleen associated tyrosine kinaseENSG0000016502513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR005189  Focal adhesion kinase, targeting (FAT) domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain
 IPR036137  Focal adhesion kinase, targeting (FAT) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001890 placenta development TAS
 biological_processGO:0001932 regulation of protein phosphorylation IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0003007 heart morphogenesis TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007097 nuclear migration IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007172 signal complex assembly IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007229 integrin-mediated signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010594 regulation of endothelial cell migration TAS
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010632 regulation of epithelial cell migration IGI
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0021955 central nervous system neuron axonogenesis IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IDA
 biological_processGO:0030010 establishment of cell polarity TAS
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IDA
 biological_processGO:0038007 netrin-activated signaling pathway TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043087 regulation of GTPase activity TAS
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity TAS
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045667 regulation of osteoblast differentiation IMP
 biological_processGO:0045860 positive regulation of protein kinase activity IMP
 biological_processGO:0046621 negative regulation of organ growth IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0048870 cell motility TAS
 biological_processGO:0050771 negative regulation of axonogenesis IEA
 biological_processGO:0051493 regulation of cytoskeleton organization TAS
 biological_processGO:0051893 regulation of focal adhesion assembly TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0051964 negative regulation of synapse assembly IEA
 biological_processGO:0060396 growth hormone receptor signaling pathway IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0097194 execution phase of apoptosis TAS
 biological_processGO:1900024 regulation of substrate adhesion-dependent cell spreading IGI
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process ISS
 biological_processGO:2000811 negative regulation of anoikis IMP
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008432 JUN kinase binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042169 SH2 domain binding IPI


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Regulation of actin dynamics for phagocytic cup formation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
NCAM signaling for neurite out-growth
Signal regulatory protein family interactions
EPHB-mediated forward signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / complex / reaction
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / complex / reaction
 ENSG00000132670 PTPRA / P18433 / protein tyrosine phosphatase, receptor type A  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000089159 PXN / P49023 / paxillin  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000214944 Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28  / complex / reaction
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000149294 NCAM1 / P13591 / neural cell adhesion molecule 1  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / reaction / complex
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction
 ENSG00000163995 ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2  / reaction / complex
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / complex / reaction
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / reaction / complex
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / reaction / complex
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction / complex
 ENSG00000173210 ABLIM3 / O94929 / actin binding LIM protein family member 3  / reaction / complex
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / reaction / complex
 ENSG00000099204 ABLIM1 / O14639 / actin binding LIM protein 1  / complex / reaction
 ENSG00000038382 TRIO / O75962 / trio Rho guanine nucleotide exchange factor  / complex / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / complex / reaction
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / reaction / complex
 ENSG00000197694 Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1  / reaction / complex
 ENSG00000120899 PTK2B / Q14289 / protein tyrosine kinase 2 beta  / reaction
 ENSG00000165806 CASP7 / P55210 / caspase 7  / reaction
 ENSG00000163554 SPTA1 / P02549 / spectrin alpha, erythrocytic 1  / reaction / complex
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / complex / reaction
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction






 

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