ENSG00000105976


Homo sapiens

Features
Gene ID: ENSG00000105976
  
Biological name :MET
  
Synonyms : MET / MET proto-oncogene, receptor tyrosine kinase / P08581
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q31.2
Gene start: 116672390
Gene end: 116798386
  
Corresponding Affymetrix probe sets: 203510_at (Human Genome U133 Plus 2.0 Array)   211599_x_at (Human Genome U133 Plus 2.0 Array)   213807_x_at (Human Genome U133 Plus 2.0 Array)   213816_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398140
Ensembl peptide - ENSP00000380860
Ensembl peptide - ENSP00000398776
Ensembl peptide - ENSP00000413857
Ensembl peptide - ENSP00000410980
Ensembl peptide - ENSP00000317272
NCBI entrez gene - 4233     See in Manteia.
OMIM - 164860
RefSeq - XM_011516223
RefSeq - NM_000245
RefSeq - NM_001127500
RefSeq - NM_001324401
RefSeq - NM_001324402
RefSeq - XM_006715990
RefSeq Peptide - NP_001311331
RefSeq Peptide - NP_000236
RefSeq Peptide - NP_001120972
RefSeq Peptide - NP_001311330
swissprot - H7C174
swissprot - C9JKM5
swissprot - A0A024R759
swissprot - P08581
swissprot - A0A024R728
swissprot - H7C130
Ensembl - ENSG00000105976
  
Related genetic diseases (OMIM): 114550 - Hepatocellular carcinoma, childhood type, somatic, 114550
  605074 - Renal cell carcinoma, papillary, 1, familial and somatic, 605074
  607278 - {Osteofibrous dysplasia, susceptibility to}, 607278
  616705 - ?Deafness, autosomal recessive 97, 616705
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 metENSDARG00000070903Danio rerio
 METENSGALG00000036883Gallus gallus
 MetENSMUSG00000009376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MST1R / Q04912 / macrophage stimulating 1 receptorENSG0000016407834
MERTK / Q12866 / MER proto-oncogene, tyrosine kinaseENSG0000015320816
AXL / P30530 / AXL receptor tyrosine kinaseENSG0000016760114
TYRO3 / Q06418 / TYRO3 protein tyrosine kinaseENSG0000009244514
TEK / Q02763 / TEK receptor tyrosine kinaseENSG0000012015613
TIE1 / P35590 / tyrosine kinase with immunoglobulin like and EGF like domains 1ENSG0000006605613
RYK / receptor-like tyrosine kinaseENSG0000016378511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR016244  Tyrosine-protein kinase, HGF/MSP receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001886 endothelial cell morphogenesis IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway NAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010507 negative regulation of autophagy NAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IDA
 biological_processGO:0035635 entry of bacterium into host cell TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0050918 positive chemotaxis IDA
 biological_processGO:0051497 negative regulation of stress fiber assembly IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0061436 establishment of skin barrier IMP
 biological_processGO:0070495 negative regulation of thrombin-activated receptor signaling pathway IDA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IDA
 biological_processGO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death IMP
 biological_processGO:1905098 negative regulation of guanyl-nucleotide exchange factor activity IDA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005008 hepatocyte growth factor-activated receptor activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
InlB-mediated entry of Listeria monocytogenes into host cell
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001395 Hepatic fibrosis 
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 HP:0001402 Hepatocellular carcinoma 
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 HP:0001413 Micronodular cirrhosis 
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 HP:0001425 Heterogeneous 
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 HP:0001428 Somatic mutation 
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 HP:0002013 Vomiting 
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 HP:0002027 Abdominal pain 
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002605 Hepatic necrosis 
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 HP:0003829 Incomplete penetrance 
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 HP:0006254 Elevated alpha-fetoprotein "An elevation of alpha-feto protein, which is produced by the fetal liver and the yolk sac and may be increased in the serum of pregnant women with a fetus with some types of developmental anomaly such as open neural tube defects and omphalaocele." [HPO:curators]
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 HP:0006572 Subacute progressive viral hepatitis 
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 HP:0006766 Papillary renal cell carcinoma 
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0030242 Portal vein thrombosis "Thrombosis of the portal vein and/or its tributaries, which include the splenic vein and the sup-erior and inferior mesenteric veins." [HPO:probinson, pmid:21960890]
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 HP:0410019 Epigastric pain "Pain that is localized to the region of the upper abdomen immediately below the ribs." [https://www.healthgrades.com/symptoms/epigastric-pain, orcid.org/0000-0001-5208-3432]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000138592 USP8 / P40818 / ubiquitin specific peptidase 8  / reaction
 ENSG00000175354 PTPN2 / P17706 / protein tyrosine phosphatase, non-receptor type 2  / reaction
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / complex / reaction
 ENSG00000136205 TNS3 / Q68CZ2 / tensin 3  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / reaction / complex
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / reaction / complex
 ENSG00000131746 TNS4 / Q8IZW8 / tensin 4  / complex / reaction
 ENSG00000085832 EPS15 / P42566 / epidermal growth factor receptor pathway substrate 15  / complex / reaction
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / complex / reaction
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / reaction / complex
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction / complex
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / reaction / complex
 ENSG00000165527 ARF6 / P62330 / ADP ribosylation factor 6  / complex
 ENSG00000160007 Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35  / complex / reaction
 ENSG00000141084 Q6VN20 / RANBP10 / RAN binding protein 10  / complex / reaction
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000010017 Q96S59 / RANBP9 / RAN binding protein 9  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000176945 MUC20 / Q8N307 / mucin 20, cell surface associated  / complex / reaction
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000144749 LRIG1 / Q96JA1 / leucine rich repeats and immunoglobulin like domains 1  / reaction / complex
 ENSG00000187764 Q92854 / SEMA4D / semaphorin 4D  / reaction / complex
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / complex
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction
 ENSG00000149177 PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type J  / reaction






 

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