ENSG00000164078


Homo sapiens

Features
Gene ID: ENSG00000164078
  
Biological name :MST1R
  
Synonyms : macrophage stimulating 1 receptor / MST1R / Q04912
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 49887002
Gene end: 49903873
  
Corresponding Affymetrix probe sets: 205455_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481084
Ensembl peptide - ENSP00000414792
Ensembl peptide - ENSP00000482642
Ensembl peptide - ENSP00000482827
Ensembl peptide - ENSP00000296474
Ensembl peptide - ENSP00000341325
Ensembl peptide - ENSP00000393294
Ensembl peptide - ENSP00000407926
NCBI entrez gene - 4486     See in Manteia.
OMIM - 600168
RefSeq - XM_011533744
RefSeq - NM_001244937
RefSeq - NM_001318913
RefSeq - NM_002447
RefSeq - XM_005265170
RefSeq - XM_011533739
RefSeq - XM_011533740
RefSeq - XM_011533741
RefSeq - XM_011533742
RefSeq - XM_011533743
RefSeq Peptide - NP_001305842
RefSeq Peptide - NP_002438
RefSeq Peptide - NP_001231866
swissprot - H7C074
swissprot - H7C3Z8
swissprot - J3KQS7
swissprot - A0A087WZG2
swissprot - Q04912
swissprot - A0A087WZQ8
swissprot - H2E272
Ensembl - ENSG00000164078
  
Related genetic diseases (OMIM): 617075 - {Nasopharyngeal carcinoma, susceptibility to, 3}, 617075
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mst1raENSDARG00000060235Danio rerio
 mst1rbENSDARG00000004871Danio rerio
 MST1RENSGALG00000003103Gallus gallus
 Mst1rENSMUSG00000032584Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MET / P08581 / MET proto-oncogene, receptor tyrosine kinaseENSG0000010597634
AXL / P30530 / AXL receptor tyrosine kinaseENSG0000016760115
TYRO3 / Q06418 / TYRO3 protein tyrosine kinaseENSG0000009244515
TEK / Q02763 / TEK receptor tyrosine kinaseENSG0000012015614
TIE1 / P35590 / tyrosine kinase with immunoglobulin like and EGF like domains 1ENSG0000006605614
MERTK / Q12866 / MER proto-oncogene, tyrosine kinaseENSG0000015320814
RYK / receptor-like tyrosine kinaseENSG0000016378512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001627  Sema domain
 IPR002909  IPT domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR016244  Tyrosine-protein kinase, HGF/MSP receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007338 single fertilization TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0038145 macrophage colony-stimulating factor signaling pathway IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005011 macrophage colony-stimulating factor receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI


Pathways (from Reactome)
Pathway description
Signaling by MST1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164078 MST1R / Q04912 / macrophage stimulating 1 receptor  / reaction / complex






 

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