ENSG00000092445


Homo sapiens

Features
Gene ID: ENSG00000092445
  
Biological name :TYRO3
  
Synonyms : Q06418 / TYRO3 / TYRO3 protein tyrosine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 41557675
Gene end: 41583586
  
Corresponding Affymetrix probe sets: 211431_s_at (Human Genome U133 Plus 2.0 Array)   211432_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452995
Ensembl peptide - ENSP00000454050
Ensembl peptide - ENSP00000455441
Ensembl peptide - ENSP00000263798
Ensembl peptide - ENSP00000453835
NCBI entrez gene - 7301     See in Manteia.
OMIM - 600341
RefSeq - XM_017022543
RefSeq - NM_006293
RefSeq - XM_017022542
RefSeq Peptide - NP_006284
RefSeq Peptide - NP_001317193
swissprot - H0YNK6
swissprot - H3BPR7
swissprot - Q06418
swissprot - H0YN24
swissprot - H0YKZ2
Ensembl - ENSG00000092445
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tyro3ENSDARG00000005356Danio rerio
 TYRO3ENSGALG00000008631Gallus gallus
 Tyro3ENSMUSG00000027298Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AXL / P30530 / AXL receptor tyrosine kinaseENSG0000016760141
MERTK / Q12866 / MER proto-oncogene, tyrosine kinaseENSG0000015320841
MST1R / Q04912 / macrophage stimulating 1 receptorENSG0000016407824
TEK / Q02763 / TEK receptor tyrosine kinaseENSG0000012015622
MET / P08581 / MET proto-oncogene, receptor tyrosine kinaseENSG0000010597622
TIE1 / P35590 / tyrosine kinase with immunoglobulin like and EGF like domains 1ENSG0000006605622
RYK / receptor-like tyrosine kinaseENSG0000016378520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling NAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021885 forebrain cell migration IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0032940 secretion by cell IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045824 negative regulation of innate immune response IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0051250 negative regulation of lymphocyte activation IEA
 biological_processGO:0060068 vagina development IEA
 biological_processGO:0070050 neuron cellular homeostasis IEA
 biological_processGO:0070527 platelet aggregation IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity NAS
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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