ENSMUSG00000027298


Mus musculus

Features
Gene ID: ENSMUSG00000027298
  
Biological name :Tyro3
  
Synonyms : P55144 / Tyro3 / TYRO3 protein tyrosine kinase 3
  
Possible biological names infered from orthology : Q06418 / TYRO3 protein tyrosine kinase
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 119797733
Gene end: 119818104
  
Corresponding Affymetrix probe sets: 10475027 (MoGene1.0st)   1425248_a_at (Mouse Genome 430 2.0 Array)   1425249_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028763
Ensembl peptide - ENSMUSP00000106410
NCBI entrez gene - 22174     See in Manteia.
MGI - MGI:104294
RefSeq - XM_017317147
RefSeq - NM_001290800
RefSeq - NM_019392
RefSeq - XM_006499160
RefSeq Peptide - NP_001277729
RefSeq Peptide - NP_062265
swissprot - P55144
Ensembl - ENSMUSG00000027298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tyro3ENSDARG00000005356Danio rerio
 TYRO3ENSGALG00000008631Gallus gallus
 TYRO3ENSG00000092445Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mertk / Q60805 / Tyrosine-protein kinase Mer / Q12866* / MER proto-oncogene, tyrosine kinase*ENSMUSG0000001436141
Axl / Q00993 / AXL receptor tyrosine kinase / P30530*ENSMUSG0000000260240
Mst1r / Q62190 / macrophage stimulating 1 receptor (c-met-related tyrosine kinase) / Q04912* / macrophage stimulating 1 receptor*ENSMUSG0000003258424
Met / MET proto-oncogene, receptor tyrosine kinase / P08581*ENSMUSG0000000937622
Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*ENSMUSG0000000638622
Tie1 / Q06806 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590*ENSMUSG0000003319122
Ryk / Q01887 / Tyrosine-protein kinase RYK / receptor-like tyrosine kinase*ENSMUSG0000003254719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007218 neuropeptide signaling pathway IMP
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021885 forebrain cell migration IGI
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0032940 secretion by cell IMP
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IGI
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0042698 ovulation cycle IGI
 biological_processGO:0043277 apoptotic cell clearance IGI
 biological_processGO:0043491 protein kinase B signaling IGI
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0045824 negative regulation of innate immune response IGI
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0051250 negative regulation of lymphocyte activation IGI
 biological_processGO:0060068 vagina development IGI
 biological_processGO:0070050 neuron cellular homeostasis IMP
 biological_processGO:0070527 platelet aggregation IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002425 altered susceptibility to autoimmune disorder "a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009008 delayed estrous cycle "onset of the sexual cycle of females occurring at a later than expected day/age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009012 short diestrus "decrease in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009014 prolonged proestrus "increase in the length of the proestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009357 induced seizures "applied stimulation producing uncontrolled electrical activity in the brain, producing a physical convulsion or minor change in physical behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0009396 small endometrial glands "decrease in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009853 decreased Sertoli cell phagocytosis "decreased phagocytic activity of testicular Sertoli cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0013508 increased granulosa cell apoptosis "increase in the timing or the number of granulsa cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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