ENSMUSG00000032547


Mus musculus

Features
Gene ID: ENSMUSG00000032547
  
Biological name :Ryk
  
Synonyms : Q01887 / Ryk / Tyrosine-protein kinase RYK
  
Possible biological names infered from orthology : receptor-like tyrosine kinase
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 102834917
Gene end: 102908305
  
Corresponding Affymetrix probe sets: 10588243 (MoGene1.0st)   1426388_s_at (Mouse Genome 430 2.0 Array)   1447400_at (Mouse Genome 430 2.0 Array)   1451789_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035142
Ensembl peptide - ENSMUSP00000135396
Ensembl peptide - ENSMUSP00000135858
NCBI entrez gene - 20187     See in Manteia.
MGI - MGI:101766
RefSeq - NM_001042607
RefSeq - NM_001284258
RefSeq - NM_013649
RefSeq Peptide - NP_038677
RefSeq Peptide - NP_001036072
RefSeq Peptide - NP_001271187
swissprot - Q01887
swissprot - H9H9R6
swissprot - H3BKH8
Ensembl - ENSMUSG00000032547
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rykENSDARG00000007231Danio rerio
 RYKENSGALG00000006488Gallus gallus
 RYKENSG00000163785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tyro3 / P55144 / TYRO3 protein tyrosine kinase 3 / Q06418* / TYRO3 protein tyrosine kinase*ENSMUSG0000002729828
Mst1r / Q62190 / macrophage stimulating 1 receptor (c-met-related tyrosine kinase) / Q04912* / macrophage stimulating 1 receptor*ENSMUSG0000003258428
Met / MET proto-oncogene, receptor tyrosine kinase / P08581*ENSMUSG0000000937627
Mertk / Q60805 / Tyrosine-protein kinase Mer / Q12866* / MER proto-oncogene, tyrosine kinase*ENSMUSG0000001436127
Axl / Q00993 / AXL receptor tyrosine kinase / P30530*ENSMUSG0000000260227
Tie1 / Q06806 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590*ENSMUSG0000003319123
Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*ENSMUSG0000000638621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003306  WIF domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007409 axonogenesis IGI
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0022038 corpus callosum development IMP
 biological_processGO:0030182 neuron differentiation IDA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0036518 chemorepulsion of dopaminergic neuron axon IGI
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048843 negative regulation of axon extension involved in axon guidance IGI
 biological_processGO:0050919 negative chemotaxis IGI
 biological_processGO:0061643 chemorepulsion of axon TAS
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:1904938 planar cell polarity pathway involved in axon guidance IGI
 biological_processGO:1904948 midbrain dopaminergic neuron differentiation IMP
 biological_processGO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISO
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017147 Wnt-protein binding TAS
 molecular_functionGO:0042813 Wnt-activated receptor activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0009906 increased tongue size "greater size the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0030095 abnormal midface morphology "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0030315 small neurocranium "decreased size of the bones of the skull enclosing the brain" [MGI:anna]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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