ENSMUSG00000032584


Mus musculus

Features
Gene ID: ENSMUSG00000032584
  
Biological name :Mst1r
  
Synonyms : macrophage stimulating 1 receptor (c-met-related tyrosine kinase) / Mst1r / Q62190
  
Possible biological names infered from orthology : macrophage stimulating 1 receptor / Q04912
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 107906873
Gene end: 107920383
  
Corresponding Affymetrix probe sets: 10588731 (MoGene1.0st)   1420461_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035203
Ensembl peptide - ENSMUSP00000142201
NCBI entrez gene - 19882     See in Manteia.
MGI - MGI:99614
RefSeq - XM_017313218
RefSeq - NM_009074
RefSeq - XM_006511654
RefSeq - XM_006511655
RefSeq - XM_006511656
RefSeq Peptide - NP_033100
swissprot - Q62190
swissprot - A0A0A6YXY9
Ensembl - ENSMUSG00000032584
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mst1raENSDARG00000060235Danio rerio
 mst1rbENSDARG00000004871Danio rerio
 MST1RENSGALG00000003103Gallus gallus
 MST1RENSG00000164078Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Met / MET proto-oncogene, receptor tyrosine kinase / P08581*ENSMUSG0000000937634
Axl / Q00993 / AXL receptor tyrosine kinase / P30530*ENSMUSG0000000260215
Tie1 / Q06806 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590*ENSMUSG0000003319115
Tyro3 / P55144 / TYRO3 protein tyrosine kinase 3 / Q06418* / TYRO3 protein tyrosine kinase*ENSMUSG0000002729815
Mertk / Q60805 / Tyrosine-protein kinase Mer / Q12866* / MER proto-oncogene, tyrosine kinase*ENSMUSG0000001436115
Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*ENSMUSG0000000638613
Ryk / Q01887 / Tyrosine-protein kinase RYK / receptor-like tyrosine kinase*ENSMUSG0000003254712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001627  Sema domain
 IPR002909  IPT domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR016244  Tyrosine-protein kinase, HGF/MSP receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005773 vacuole IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PhexHyp/PhexHyp
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

Allelic Composition: Mst1rFv2-s/Mst1rFv2-s
Genetic Background: either: BALB/cCrgl or DBA/2Crgl or Swiss

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Grid2tpr/Grid2tpr
Genetic Background: involves: B10.D2/nSnJ

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Mst1rtm1.1Sew/Mst1rtm1.1Sew
Genetic Background: involves: 129/Ola * CD-1 * NIH Black Swiss

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mst1rtm2(Mst1r*)Sew/Mst1rtm2(Mst1r*)Sew
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mst1rtm1.1Sew/Mst1rtm1.1Sew
Genetic Background: involves: 129/Ola * CD-1 * NIH Black Swiss

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arxtm1Gldn/Y,Tg(Pou3f4-cre)32Cren/0
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mst1rtm1Sjd/Mst1r+
Genetic Background: either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: PhexHyp/PhexHyp
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

Allelic Composition: Mst1rFv2-s/Mst1rFv2-s
Genetic Background: either: BALB/cCrgl or DBA/2Crgl or Swiss

Allelic Composition: Mst1rFv2-s/Mst1rFv2-s
Genetic Background: C3H/Crgl

Allelic Composition: Mst1rtm2(Mst1r*)Sew/Mst1rtm2(Mst1r*)Sew
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mst1rtm1Sjd/Mst1r+
Genetic Background: either: (involves: 129 * C57BL/6) or (involves: 129 * CD-1) or (involves: 129 * NIH Black Swiss)

Allelic Composition: Mst1rtm1.1Sew/Mst1rtm1.1Sew
Genetic Background: involves: 129/Ola * CD-1 * NIH Black Swiss

 MP:0002534 type IV hypersensitivity reaction "an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mst1rtm1.1Sew/Mst1rtm1.1Sew
Genetic Background: involves: 129/Ola * CD-1 * NIH Black Swiss

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mst1rtm2(Mst1r*)Sew/Mst1rtm2(Mst1r*)Sew
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mst1rtm2(Mst1r*)Sew/Mst1rtm2(Mst1r*)Sew
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Mst1rtm1.1Sew/Mst1rtm1.1Sew
Genetic Background: involves: 129/Ola * CD-1 * NIH Black Swiss

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Mst1rtm2(Mst1r*)Sew/Mst1rtm2(Mst1r*)Sew
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Mst1rtm2(Mst1r*)Sew/Mst1rtm2(Mst1r*)Sew
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mst1rtm1.1Sew/Mst1rtm1.1Sew
Genetic Background: involves: 129/Ola * CD-1 * NIH Black Swiss

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mst1rtm2(Mst1r*)Sew/Mst1rtm2(Mst1r*)Sew
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: A/?,DctSlt-lt/DctSlt-lt
Genetic Background: involves: C3H/HeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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