ENSMUSG00000014361


Mus musculus

Features
Gene ID: ENSMUSG00000014361
  
Biological name :Mertk
  
Synonyms : Mertk / Q60805 / Tyrosine-protein kinase Mer
  
Possible biological names infered from orthology : MER proto-oncogene, tyrosine kinase / Q12866
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 128698956
Gene end: 128802894
  
Corresponding Affymetrix probe sets: 10475890 (MoGene1.0st)   1422869_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014505
NCBI entrez gene - 17289     See in Manteia.
MGI - MGI:96965
RefSeq - NM_008587
RefSeq - XM_006498860
RefSeq Peptide - NP_032613
swissprot - Q60805
Ensembl - ENSMUSG00000014361
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mertkaENSDARG00000074695Danio rerio
 MERTKENSGALG00000008257Gallus gallus
 MERTKENSG00000153208Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Axl / Q00993 / AXL receptor tyrosine kinase / P30530*ENSMUSG0000000260238
Tyro3 / P55144 / TYRO3 protein tyrosine kinase 3 / Q06418* / TYRO3 protein tyrosine kinase*ENSMUSG0000002729836
Mst1r / Q62190 / macrophage stimulating 1 receptor (c-met-related tyrosine kinase) / Q04912* / macrophage stimulating 1 receptor*ENSMUSG0000003258421
Met / MET proto-oncogene, receptor tyrosine kinase / P08581*ENSMUSG0000000937621
Tie1 / Q06806 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590*ENSMUSG0000003319120
Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*ENSMUSG0000000638619
Ryk / Q01887 / Tyrosine-protein kinase RYK / receptor-like tyrosine kinase*ENSMUSG0000003254716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IGI
 biological_processGO:0001818 negative regulation of cytokine production IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0032940 secretion by cell IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0043277 apoptotic cell clearance IMP
 biological_processGO:0043491 protein kinase B signaling IGI
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0051250 negative regulation of lymphocyte activation IGI
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060068 vagina development IGI
 biological_processGO:0097350 neutrophil clearance IGI
 biological_processGO:2000107 negative regulation of leukocyte apoptotic process IEA
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016028 rhabdomere IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(B2M)55Hpl/0,Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic Background: NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Tg(B2M)55Hpl/Sz

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl
Genetic Background: involves: C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mertknmf12/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk,Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mertknmf12/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002425 altered susceptibility to autoimmune disorder "a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl
Genetic Background: involves: C57BL/6J

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004906 enlarged uterus 
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005548 retinal pigment epithelium atrophy "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005673 decreased susceptibility to graft versus host disease "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Mertktm1Gkm Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008247 abnormal mononuclear leukocyte morphology "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
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Allelic Composition: Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk,Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk,Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

Allelic Composition: Mertknmf12/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk,Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

Allelic Composition: Mertknmf12/Mertknmf12,Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

 MP:0009396 small endometrial glands "decrease in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0009853 decreased Sertoli cell phagocytosis "decreased phagocytic activity of testicular Sertoli cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl
Genetic Background: involves: C57BL/6J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Lpltm1Sem/Lpl+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013508 increased granulosa cell apoptosis "increase in the timing or the number of granulsa cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Mertknmf12/Mertknmf12
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022912 Pros1 / Q08761 / protein S (alpha) / P07225* / protein S*  / complex / reaction
 ENSMUSG00000031451 Gas6 / Q61592 / Growth arrest-specific protein 6 / Q14393* / growth arrest specific 6*  / complex / reaction






 

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