ENSMUSG00000022912


Mus musculus

Features
Gene ID: ENSMUSG00000022912
  
Biological name :Pros1
  
Synonyms : Pros1 / protein S (alpha) / Q08761
  
Possible biological names infered from orthology : P07225 / protein S
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C1.3
Gene start: 62854307
Gene end: 62929346
  
Corresponding Affymetrix probe sets: 10436456 (MoGene1.0st)   1426246_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023629
NCBI entrez gene - 19128     See in Manteia.
MGI - MGI:1095733
RefSeq - XM_011245843
RefSeq - NM_011173
RefSeq Peptide - NP_035303
swissprot - Q08761
swissprot - Q3TR66
Ensembl - ENSMUSG00000022912
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pros1ENSDARG00000068261Danio rerio
 PROS1ENSGALG00000015409Gallus gallus
 PROS1ENSG00000184500Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gas6 / Q61592 / Growth arrest-specific protein 6 / Q14393* / growth arrest specific 6*ENSMUSG0000003145139
Shbg / P97497 / Sex hormone-binding globulin / P04278*ENSMUSG0000000520212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR033189  Vitamin K-dependent protein S
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0030195 negative regulation of blood coagulation IEA
 biological_processGO:0042730 fibrinolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000606 decreased hepatocyte number "fewer than normal number of parenchymal liver cells" [J:23170]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Pros1tm1.1Ansc/Pros1tm1.1Ansc
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pros1tm1.1Ansc/Pros1tm1.1Ansc
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pros1tm1.1Ansc/Pros1tm1.1Ansc
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

Allelic Composition: Pros1tm1Grl/Pros1tm1Grl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * DBA

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Pros1tm1.1Ansc/Pros1tm1.1Ansc
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0009275 bruising "an injury to biological tissue in which the capillaries are damaged, allowing blood to seep into the surrounding tissue; it should not be confused with ecchymosis, though the terms are related" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pros1tm1.1Ansc/Pros1tm1.1Ansc
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1Wpfl/Abca1tm1Wpfl,Npc1m1N/Npc1m1N
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010022 brain vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the brain" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Pros1tm1.1Ansc/Pros1tm1.1Ansc
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lhx6tm2Vpa/Lhx6tm2Vpa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Pros1tm1.2Grl/Pros1tm1.2Grl
Genetic Background: involves: 129S1/SvImJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014361 Mertk / Q60805 / Tyrosine-protein kinase Mer / Q12866* / MER proto-oncogene, tyrosine kinase*  / reaction / complex
 ENSMUSG00000053460 Ggcx / Q9QYC7 / Vitamin K-dependent gamma-carboxylase / P38435* / gamma-glutamyl carboxylase*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr