ENSMUSG00000030530


Mus musculus

Features
Gene ID: ENSMUSG00000030530
  
Biological name :Furin
  
Synonyms : Furin / P23188
  
Possible biological names infered from orthology : furin, paired basic amino acid cleaving enzyme / P09958
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 80388585
Gene end: 80405436
  
Corresponding Affymetrix probe sets: 10564960 (MoGene1.0st)   1418518_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116734
Ensembl peptide - ENSMUSP00000113793
Ensembl peptide - ENSMUSP00000121028
Ensembl peptide - ENSMUSP00000146304
Ensembl peptide - ENSMUSP00000102985
Ensembl peptide - ENSMUSP00000113370
NCBI entrez gene - 18550     See in Manteia.
MGI - MGI:97513
RefSeq - XM_011250823
RefSeq - NM_011046
RefSeq - XM_011250818
RefSeq - XM_011250819
RefSeq - XM_011250820
RefSeq - XM_011250821
RefSeq - XM_011250822
RefSeq - NM_001081454
RefSeq Peptide - NP_001074923
RefSeq Peptide - NP_035176
swissprot - D3Z401
swissprot - D3YTP7
swissprot - P23188
swissprot - A0A0U1RQ98
Ensembl - ENSMUSG00000030530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 furinaENSDARG00000062909Danio rerio
 furinbENSDARG00000070971Danio rerio
 FURINENSGALG00000008341Gallus gallus
 FURINENSG00000140564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcsk5 / Q04592 / Proprotein convertase subtilisin/kexin type 5 / Q92824*ENSMUSG0000002471347
Pcsk4 / P29121 / Proprotein convertase subtilisin/kexin type 4 / Q6UW60*ENSMUSG0000002013145
Pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*ENSMUSG0000003051345
Pcsk1 / P63239 / Neuroendocrine convertase 1 / P29120* / proprotein convertase subtilisin/kexin type 1*ENSMUSG0000002158740
Pcsk2 / P21661 / proprotein convertase subtilisin/kexin type 2 / P16519*ENSMUSG0000002741935
Pcsk7 / Q61139 / Proprotein convertase subtilisin/kexin type 7 / Q16549*ENSMUSG0000003538234


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR002884  P domain
 IPR006212  Furin-like repeat
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023827  Peptidase S8, subtilisin, Asp-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR032815  Peptidase S8, pro-domain
 IPR034182  Kexin/furin catalytic domain
 IPR036852  Peptidase S8/S53 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006465 signal peptide processing ISO
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008283 cell proliferation ISO
 biological_processGO:0009966 regulation of signal transduction IDA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016485 protein processing ISO
 biological_processGO:0016486 peptide hormone processing ISO
 biological_processGO:0019058 viral life cycle IEA
 biological_processGO:0031638 zymogen activation ISO
 biological_processGO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process ISO
 biological_processGO:0032902 nerve growth factor production ISO
 biological_processGO:0032911 negative regulation of transforming growth factor beta1 production ISO
 biological_processGO:0032940 secretion by cell ISO
 biological_processGO:0042176 regulation of protein catabolic process ISO
 biological_processGO:0043043 peptide biosynthetic process ISO
 biological_processGO:0045714 regulation of low-density lipoprotein particle receptor biosynthetic process IMP
 biological_processGO:0052548 regulation of endopeptidase activity ISO
 biological_processGO:0090472 dibasic protein processing ISO
 cellular_componentGO:0000139 Golgi membrane ISO
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0012510 trans-Golgi network transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0030140 trans-Golgi network transport vesicle ISO
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0004175 endopeptidase activity ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048406 nerve growth factor binding ISO


Pathways (from Reactome)
Pathway description
Collagen degradation
Elastic fibre formation
Activation of Matrix Metalloproteinases
Removal of aminoterminal propeptides from gamma-carboxylated proteins
NGF processing
Signaling by PDGF
Pre-NOTCH Processing in Golgi
TGF-beta receptor signaling activates SMADs
Formation of the cornified envelope
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
Show

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitlSl-17H/KitlSl-17H
Genetic Background: C3H/HeH-KitlSl-17H

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ftsj1tm1b(EUCOMM)Wtsi/Ftsj1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ftsj1tm1b(EUCOMM)Wtsi/Bay

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Furintm1.1Jwmc/Furintm1.1Jwmc
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ftsj1tm1b(EUCOMM)Wtsi/Ftsj1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ftsj1tm1b(EUCOMM)Wtsi/Bay

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003384 abnormal ventral body wall "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009706 absent midgut "absence of the portion of the embryonic gut between the foregut and the hindgut" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Furintm1.1Jwmc/Furintm1.1Jwmc
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ftsj1tm1b(EUCOMM)Wtsi/Ftsj1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ftsj1tm1b(EUCOMM)Wtsi/Bay

 MP:0011189 small embryonic epiblast "reduced size of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
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Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012173 short rostral-caudal axis "length reduction or truncation of the axis that runs from the head to the tail of the body" [MGI:anna]
Show

Allelic Composition: Furintm1Ajmr/Furintm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
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Allelic Composition: Pcsk1tm1Dfs/Pcsk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Ftsj1tm1b(EUCOMM)Wtsi/Ftsj1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ftsj1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction
 ENSMUSG00000074483 Bglap / P86546 / Osteocalcin / P02818* / bone gamma-carboxyglutamate protein*  / reaction
 ENSMUSG00000031444 F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*  / reaction
 ENSMUSG00000037171 Nodal / P43021 / Q96S42* / nodal growth differentiation factor*  / reaction
 ENSMUSG00000031445 Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*  / reaction
 ENSMUSG00000028226 Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*  / reaction
 ENSMUSG00000074486 Bglap2 / P86547 / Osteocalcin-2 / BGLAP* / P02818* / bone gamma-carboxyglutamate protein*  / reaction
 ENSMUSG00000015568 Lpl / P11152 / lipoprotein lipase / P06858*  / reaction
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / reaction
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / reaction
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / reaction
 ENSMUSG00000022579 Q9D1N2 / Gpihbp1 / GPI-anchored HDL-binding protein 1 / Q8IV16* / glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1*  / reaction
 ENSMUSG00000000901 Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*  / reaction
 ENSMUSG00000063564 Q8K4G2 / Col23a1 / Collagen alpha-1(XXIII) chain / Q86Y22* / collagen type XXIII alpha 1 chain*  / reaction
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / reaction
 ENSMUSG00000000957 Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*  / reaction
 ENSMUSG00000031451 Gas6 / Q61592 / Growth arrest-specific protein 6 / Q14393* / growth arrest specific 6*  / reaction
 ENSMUSG00000022912 Pros1 / Q08761 / protein S (alpha) / P07225* / protein S*  / reaction
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / reaction
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction
 ENSMUSG00000031443 F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*  / reaction
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / reaction
 ENSMUSG00000074489 Bglap3 / P54615 / Osteocalcin-related protein / BGLAP* / P02818* / bone gamma-carboxyglutamate protein*  / reaction






 

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