ENSMUSG00000022579


Mus musculus

Features
Gene ID: ENSMUSG00000022579
  
Biological name :Gpihbp1
  
Synonyms : GPI-anchored HDL-binding protein 1 / Gpihbp1 / Q9D1N2
  
Possible biological names infered from orthology : glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 / Q8IV16
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 75596628
Gene end: 75599481
  
Corresponding Affymetrix probe sets: 10424695 (MoGene1.0st)   1453022_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139511
Ensembl peptide - ENSMUSP00000139792
Ensembl peptide - ENSMUSP00000023243
NCBI entrez gene - 68453     See in Manteia.
MGI - MGI:1915703
RefSeq - NM_026730
RefSeq - XM_017316736
RefSeq - NM_001347039
RefSeq Peptide - NP_001333968
RefSeq Peptide - NP_081006
swissprot - A0A087WNV7
swissprot - Q9D1N2
swissprot - A0A087WPI6
Ensembl - ENSMUSG00000022579
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8IV16ENSG00000277494Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016054  Ly-6 antigen/uPA receptor-like
 IPR018363  CD59 antigen, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IDA
 biological_processGO:0006886 intracellular protein transport IDA
 biological_processGO:0017038 protein import IDA
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0045056 transcytosis IDA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IMP
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:0071806 protein transmembrane transport IEA
 biological_processGO:0090319 positive regulation of chylomicron remodeling IC
 biological_processGO:0090321 positive regulation of chylomicron remnant clearance IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IDA
 molecular_functionGO:0008035 high-density lipoprotein particle binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008320 protein transmembrane transporter activity IDA
 molecular_functionGO:0035473 lipase binding IPI
 molecular_functionGO:0035478 chylomicron binding IMP
 molecular_functionGO:0071813 lipoprotein particle binding IMP


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins
Assembly of active LPL and LIPC lipase complexes
Chylomicron remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic Background: involves: 129S6/SvEvTac * 129/Sv

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb,Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic Background: involves: 129S6/SvEvTac * 129/Sv

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic Background: involves: 129S6/SvEvTac * 129/Sv

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic Background: involves: 129S6/SvEvTac * 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015568 Lpl / P11152 / lipoprotein lipase / P06858*  / reaction / complex
 ENSMUSG00000024713 Pcsk5 / Q04592 / Proprotein convertase subtilisin/kexin type 5 / Q92824*  / reaction
 ENSMUSG00000030513 Pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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