Manteia - Molecule gene

ENSMUSG00000015568

Mus musculus

Features

Gene ID:	ENSMUSG00000015568

Biological name :	Lpl

Synonyms :	lipoprotein lipase / Lpl / P11152

Possible biological names infered from orthology :	P06858

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	B3.3
Gene start:	68880491
Gene end:	68907448

Corresponding Affymetrix probe sets:	10572130 (MoGene1.0st) 1415904_at (Mouse Genome 430 2.0 Array) 1431056_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000015712 Ensembl peptide - ENSMUSP00000132259 NCBI entrez gene - 16956 See in Manteia. MGI - MGI:96820 RefSeq - NM_008509 RefSeq Peptide - NP_032535 swissprot - P11152 Ensembl - ENSMUSG00000015568

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
FP245456.1	ENSDARG00000098720	Danio rerio
lpl	ENSDARG00000087697	Danio rerio
LPL	ENSGALG00000015425	Gallus gallus
LPL	ENSG00000175445	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lipg / Q9WVG5 / Endothelial lipase / Q9Y5X9* / lipase G, endothelial type*	ENSMUSG00000053846	47
Lipc / P27656 / Hepatic triacylglycerol lipase / P11150* / lipase C, hepatic type*	ENSMUSG00000032207	43
Q5BKQ4 / Pnliprp1 / pancreatic lipase related protein 1 / P54315*	ENSMUSG00000042179	28
P17892 / Pnliprp2 / pancreatic lipase-related protein 2 / pancreatic lipase related protein 2 (gene/pseudogene)*	ENSMUSG00000025091	26
Pnlip / Q6P8U6 / pancreatic lipase / P16233*	ENSMUSG00000046008	26
Liph / Q8CIV3 / Lipase member H / Q8WWY8* / lipase H*	ENSMUSG00000044626	25
Lipi / lipase I / Q6XZB0*	ENSMUSG00000032948	24
Pla1a / Q8VI78 / Phospholipase A1 member A / Q53H76*	ENSMUSG00000002847	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000734	Triacylglycerol lipase family
IPR001024	PLAT/LH2 domain
IPR002330	Lipoprotein lipase
IPR013818	Lipase/vitellogenin
IPR016272	Lipase, LIPH-type
IPR029058	Alpha/Beta hydrolase fold
IPR033906	Lipase, N-terminal
IPR036392	PLAT/LH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006633	fatty acid biosynthetic process	ISO
biological_process	GO:0009409	response to cold	IEA
biological_process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	IGI
biological_process	GO:0010886	positive regulation of cholesterol storage	ISO
biological_process	GO:0010890	positive regulation of sequestering of triglyceride	ISO
biological_process	GO:0016042	lipid catabolic process	IEA
biological_process	GO:0019432	triglyceride biosynthetic process	ISO
biological_process	GO:0019433	triglyceride catabolic process	IDA
biological_process	GO:0034372	very-low-density lipoprotein particle remodeling	ISO
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0042632	cholesterol homeostasis	ISO
biological_process	GO:0055096	low-density lipoprotein particle mediated signaling	ISO
biological_process	GO:0070328	triglyceride homeostasis	ISO
biological_process	GO:0090197	positive regulation of chemokine secretion	ISO
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	ISO
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0031012	extracellular matrix	IEA
cellular_component	GO:0031225	anchored component of membrane	IEA
cellular_component	GO:0034361	very-low-density lipoprotein particle	IEA
cellular_component	GO:0042627	chylomicron	IEA
molecular_function	GO:0004465	lipoprotein lipase activity	ISO
molecular_function	GO:0004806	triglyceride lipase activity	IDA
molecular_function	GO:0005102	signaling receptor binding	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008201	heparin binding	ISS
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0017129	triglyceride binding	IEA
molecular_function	GO:0034185	apolipoprotein binding	ISO
molecular_function	GO:0052689	carboxylic ester hydrolase activity	IEA

Pathways (from Reactome)

Pathway description

Assembly of active LPL and LIPC lipase complexes

Chylomicron remodeling

Retinoid metabolism and transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000003	abnormal adipose tissue morphology	"structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0000180	abnormal circulating cholesterol level	"anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified Allelic Composition: Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0001177	atelectasis	"collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Il10rb^tm1Agt/Il10rb^tm1Agt,Tg(Cd4-TGFBR2)16Flv/? Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lep^ob/Lep^ob Genetic Background: FVB.Cg-Lep^ob/Chua Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Col2a1^tm1(SOX9)Crm/Col2a1⁺,Sox9^tm1Crm/Sox9⁺ Genetic Background: involves: 129S4/SvJae Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0001548	hyperlipidemia	"abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd
MP:0001556	increased circulating HDL cholesterol level	"higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]	Show Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cap2^{tm1e(EUCOMM)Wtsi}/Cap2^{tm1e(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Cap2^{tm1e(EUCOMM)Wtsi}
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Col2a1^tm1(SOX9)Crm/Col2a1⁺,Sox9^tm1Crm/Sox9⁺ Genetic Background: involves: 129S4/SvJae Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0002753	dilated left ventricle	"an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N
MP:0003658	abnormal capillaries	"malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0003819	increased left ventricle diastolic pressure	"increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]	Show Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N
MP:0003820	increased left ventricle systolic pressure	"increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]	Show Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N
MP:0003949	abnormal circulating lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd
MP:0003975	increased circulating VLDL triglyceride level	"higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003980	increased circulating phospholipid level	"greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003982	increased cholesterol level	"greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae
MP:0004007	abnormal lung vasculature	"malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified
MP:0004883	abnormal blood vessel healing	"anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N
MP:0005145	increased circulating VLDL cholesterol level	"greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Lpl^tm1Sem/Lpl⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd
MP:0005280	abnormal fatty acid level	"anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Col2a1^tm1(SOX9)Crm/Col2a1⁺,Sox9^tm1Crm/Sox9⁺ Genetic Background: involves: 129S4/SvJae
MP:0005281	increased fatty acid level	"higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0005317	increased triglyceride level	"higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Col2a1^tm1(SOX9)Crm/Col2a1⁺,Sox9^tm1Crm/Sox9⁺ Genetic Background: involves: 129S4/SvJae Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae
MP:0005330	cardiomyopathy	"diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0005608	cardiac interstitial fibrosis	"formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N
MP:0008908	increased total fat pad weight	"greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺ Genetic Background: involves: 129S4/SvJae
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N
MP:0010018	lung vascular congestion	"obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010019	liver vascular congestion	"obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0010630	abnormal cardiac muscle tissue morphology	"any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lpl^tm1Bres/Lpl⁺,Tg(Myh6-LPL)357Ijg/0 Genetic Background:* involves: 129S4/SvJae
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Erbb2^tm1Vrtn/Erbb2^tm1Vrtn Genetic Background: Not Specified Allelic Composition: Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0020408	altered susceptibility to induced thrombosis	"any anomaly in the formation of thrombi following mechanical or chemical stimulation of thrombosis" [PMID:16614756, PMID:9262402]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Lpl^tm1Sem/Lpl^tm1Sem Genetic Background: involves: 129P2/OlaHsd
MP:0030018	increased cardiac cell glucose uptake	"increased ability of the cells of the heart to take in glucose" [MGI:anna]	Show Allelic Composition: Col2a1^tm1(SOX9)Crm/Col2a1⁺,Sox9^tm1Crm/Sox9⁺ Genetic Background: involves: 129S4/SvJae Allelic Composition: Lpl^tm1Ijg/Lpl^tm1Ijg,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: FVB/N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000015568	Lpl / P11152 / lipoprotein lipase / P06858*	/ complex
ENSMUSG00000022579	Q9D1N2 / Gpihbp1 / GPI-anchored HDL-binding protein 1 / Q8IV16* / glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1*	/ complex / reaction
ENSMUSG00000024713	Pcsk5 / Q04592 / Proprotein convertase subtilisin/kexin type 5 / Q92824*	/ reaction
ENSMUSG00000030513	Pcsk6 / proprotein convertase subtilisin/kexin type 6 / P29122*	/ reaction
ENSMUSG00000030530	Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*	/ reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr