ENSMUSG00000046008


Mus musculus

Features
Gene ID: ENSMUSG00000046008
  
Biological name :Pnlip
  
Synonyms : pancreatic lipase / Pnlip / Q6P8U6
  
Possible biological names infered from orthology : P16233
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 58670365
Gene end: 58681786
  
Corresponding Affymetrix probe sets: 10464298 (MoGene1.0st)   1421868_a_at (Mouse Genome 430 2.0 Array)   1433431_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056377
NCBI entrez gene - 69060     See in Manteia.
MGI - MGI:97722
RefSeq - NM_026925
RefSeq Peptide - NP_081201
swissprot - Q6P8U6
Ensembl - ENSMUSG00000046008
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PNLIPENSGALG00000009231Gallus gallus
 PNLIPENSG00000175535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P17892 / Pnliprp2 / pancreatic lipase-related protein 2 / pancreatic lipase related protein 2 (gene/pseudogene)*ENSMUSG0000002509169
Q5BKQ4 / Pnliprp1 / pancreatic lipase related protein 1 / P54315*ENSMUSG0000004217966
Lipc / P27656 / Hepatic triacylglycerol lipase / P11150* / lipase C, hepatic type*ENSMUSG0000003220728
Lipg / Q9WVG5 / Endothelial lipase / Q9Y5X9* / lipase G, endothelial type*ENSMUSG0000005384628
Lipi / lipase I / Q6XZB0*ENSMUSG0000003294827
Liph / Q8CIV3 / Lipase member H / Q8WWY8* / lipase H*ENSMUSG0000004462627
Lpl / P11152 / lipoprotein lipase / P06858*ENSMUSG0000001556826
Pla1a / Q8VI78 / Phospholipase A1 member A / Q53H76*ENSMUSG0000000284726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000734  Triacylglycerol lipase family
 IPR001024  PLAT/LH2 domain
 IPR002331  Pancreatic lipase
 IPR013818  Lipase/vitellogenin
 IPR016272  Lipase, LIPH-type
 IPR029058  Alpha/Beta hydrolase fold
 IPR033906  Lipase, N-terminal
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process ISO
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030299 intestinal cholesterol absorption IMP
 biological_processGO:0061365 positive regulation of triglyceride lipase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004806 triglyceride lipase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016298 lipase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Digestion of dietary lipid
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002647 decreased cholesterol absorption "reduced ability of the body to take in these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005365 abnormal bile salt homeostasis "anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]
Show

Allelic Composition: Cryaatm1Wawr/Cryaa+
Genetic Background: involves: 129/Sv * 129S4/SvJae

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Celtm1Dyh/Celtm1Dyh,Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pnliptm1Dyh/Pnliptm1Dyh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024225 Clps / Q9CQC2 / Colipase / P04118*  / complex






 

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