ENSMUSG00000053846


Mus musculus

Features
Gene ID: ENSMUSG00000053846
  
Biological name :Lipg
  
Synonyms : Endothelial lipase / Lipg / Q9WVG5
  
Possible biological names infered from orthology : lipase G, endothelial type / Q9Y5X9
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E2
Gene start: 74939322
Gene end: 74961263
  
Corresponding Affymetrix probe sets: 10459772 (MoGene1.0st)   1421261_at (Mouse Genome 430 2.0 Array)   1421262_at (Mouse Genome 430 2.0 Array)   1450188_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066536
NCBI entrez gene - 16891     See in Manteia.
MGI - MGI:1341803
RefSeq - XM_006525692
RefSeq - NM_010720
RefSeq Peptide - NP_034850
swissprot - Q9WVG5
swissprot - C0LQ91
Ensembl - ENSMUSG00000053846
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lipgENSDARG00000031044Danio rerio
 LIPGENSGALG00000043734Gallus gallus
 LIPGENSG00000101670Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lpl / P11152 / lipoprotein lipase / P06858*ENSMUSG0000001556845
Lipc / P27656 / Hepatic triacylglycerol lipase / P11150* / lipase C, hepatic type*ENSMUSG0000003220741
Pnlip / Q6P8U6 / pancreatic lipase / P16233*ENSMUSG0000004600826
Q5BKQ4 / Pnliprp1 / pancreatic lipase related protein 1 / P54315*ENSMUSG0000004217926
Pla1a / Q8VI78 / Phospholipase A1 member A / Q53H76*ENSMUSG0000000284725
Liph / Q8CIV3 / Lipase member H / Q8WWY8* / lipase H*ENSMUSG0000004462625
P17892 / Pnliprp2 / pancreatic lipase-related protein 2 / pancreatic lipase related protein 2 (gene/pseudogene)*ENSMUSG0000002509125
Lipi / lipase I / Q6XZB0*ENSMUSG0000003294824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000734  Triacylglycerol lipase family
 IPR001024  PLAT/LH2 domain
 IPR002330  Lipoprotein lipase
 IPR013818  Lipase/vitellogenin
 IPR016272  Lipase, LIPH-type
 IPR029058  Alpha/Beta hydrolase fold
 IPR033906  Lipase, N-terminal
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0010983 positive regulation of high-density lipoprotein particle clearance ISO
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032376 positive regulation of cholesterol transport ISO
 biological_processGO:0034375 high-density lipoprotein particle remodeling ISO
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043691 reverse cholesterol transport ISO
 biological_processGO:0050746 regulation of lipoprotein metabolic process IMP
 biological_processGO:0055091 phospholipid homeostasis ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0004465 lipoprotein lipase activity ISO
 molecular_functionGO:0004620 phospholipase activity ISO
 molecular_functionGO:0004806 triglyceride lipase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008970 phosphatidylcholine 1-acylhydrolase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
HDL remodeling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0000184 abnormal circulating HDL cholesterol level "anomalous concentration in the blood of high denisty lipoprotein; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Lipgtm1Tq/Lipg+
Genetic Background: B6.129S6-Lipgtm1Tq

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: B6.129S6-Lipgtm1Tq

Allelic Composition: Lipgtm1Tq/Lipg+
Genetic Background: B6.129S6-Lipgtm1Tq

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003980 increased circulating phospholipid level "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: B6.129S6-Lipgtm1Tq

Allelic Composition: Lipgtm1Tq/Lipg+
Genetic Background: B6.129S6-Lipgtm1Tq

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: B6.129S6-Lipgtm1Tq

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg,Abl2tm1Ajk/Abl2tm1Ajk
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Allelic Composition: Lipgtm1Chan/Lipg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lipgtm1Tq/Lipgtm1Tq
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053846 Lipg / Q9WVG5 / Endothelial lipase / Q9Y5X9* / lipase G, endothelial type*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr