ENSMUSG00000074483


Mus musculus

Features
Gene ID: ENSMUSG00000074483
  
Biological name :Bglap
  
Synonyms : Bglap / Osteocalcin / P86546
  
Possible biological names infered from orthology : bone gamma-carboxyglutamate protein / P02818
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 88383501
Gene end: 88384464
  
Corresponding Affymetrix probe sets: 10499358 (MoGene1.0st)   10499363 (MoGene1.0st)   1449880_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075425
NCBI entrez gene - 12096     See in Manteia.
MGI - MGI:88156
RefSeq - NM_007541
RefSeq Peptide - NP_031567
swissprot - P86546
Ensembl - ENSMUSG00000074483
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BGLAPENSGALG00000029494Gallus gallus
 BGLAPENSG00000242252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bglap2 / P86547 / Osteocalcin-2 / BGLAP* / P02818* / bone gamma-carboxyglutamate protein*ENSMUSG0000007448697
Bglap3 / P54615 / Osteocalcin-related protein / BGLAP* / P02818* / bone gamma-carboxyglutamate protein*ENSMUSG0000007448991


Protein motifs (from Interpro)
Interpro ID Name
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR002384  Osteocalcin/matrix Gla protein
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0071773 cellular response to BMP stimulus IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap/Bglap2tm3.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Ptprvtm1Asmi/Ptprv+
Genetic Background: involves: 129P2/OlaHsd * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap/Bglap2tm3.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap/Bglap2tm3.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004149 increased bone strength "increased ability of bone to endure the application of force without yielding or breaking" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap/Bglap2tm3.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoq+,Bglap/Bglap2tm1Kry/Bglap+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap/Bglap2tm3.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap/Bglap2tm3.1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB

Allelic Composition: Bglap/Bglap2tm3.1Kry/Bglap+,Gprc6atm1.1Kry/Gprc6a+,Tg(Cyp17a1-icre)AJako/0
Genetic Background: Not Specified

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Adipoqtm1Ish/Adipoq+,Bglap/Bglap2tm1Kry/Bglap+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000053460 Ggcx / Q9QYC7 / Vitamin K-dependent gamma-carboxylase / P38435* / gamma-glutamyl carboxylase*  / reaction
 ENSMUSG00000030530 Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*  / reaction






 

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