ENSG00000242252


Homo sapiens

Features
Gene ID: ENSG00000242252
  
Biological name :BGLAP
  
Synonyms : BGLAP / bone gamma-carboxyglutamate protein / P02818
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q22
Gene start: 156241962
Gene end: 156243321
  
Corresponding Affymetrix probe sets: 206956_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357255
NCBI entrez gene - 632     See in Manteia.
OMIM - 112260
RefSeq - NM_199173
RefSeq Peptide - NP_954642
swissprot - P02818
Ensembl - ENSG00000242252
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BGLAPENSGALG00000029494Gallus gallus
 BglapENSMUSG00000074483Mus musculus
 Bglap2ENSMUSG00000074486Mus musculus
 Bglap3ENSMUSG00000074489Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR002384  Osteocalcin/matrix Gla protein
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006465 signal peptide processing TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0017187 peptidyl-glutamic acid carboxylation TAS
 biological_processGO:0030282 bone mineralization NAS
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032571 response to vitamin K IEA
 biological_processGO:0033280 response to vitamin D IEP
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0033594 response to hydroxyisoflavone IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045124 regulation of bone resorption NAS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045670 regulation of osteoclast differentiation NAS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0005198 structural molecule activity NAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008147 structural constituent of bone NAS
 molecular_functionGO:0046848 hydroxyapatite binding NAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
RUNX2 regulates osteoblast differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115486 GGCX / P38435 / gamma-glutamyl carboxylase  / reaction
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction






 

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