ENSMUSG00000053460


Mus musculus

Features
Gene ID: ENSMUSG00000053460
  
Biological name :Ggcx
  
Synonyms : Ggcx / Q9QYC7 / Vitamin K-dependent gamma-carboxylase
  
Possible biological names infered from orthology : gamma-glutamyl carboxylase / P38435
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 72414308
Gene end: 72430712
  
Corresponding Affymetrix probe sets: 10539119 (MoGene1.0st)   1423554_at (Mouse Genome 430 2.0 Array)   1445898_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070109
Ensembl peptide - ENSMUSP00000146123
Ensembl peptide - ENSMUSP00000146112
Ensembl peptide - ENSMUSP00000145976
Ensembl peptide - ENSMUSP00000145557
NCBI entrez gene - 56316     See in Manteia.
MGI - MGI:1927655
RefSeq - XM_006506416
RefSeq - NM_019802
RefSeq - XM_006506414
RefSeq Peptide - NP_062776
swissprot - A0A0U1RPU0
swissprot - B2RS80
swissprot - A0A0U1RNG6
swissprot - Q9QYC7
swissprot - A0A0U1RPT2
swissprot - A0A0U1RPG7
Ensembl - ENSMUSG00000053460
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ggcxENSDARG00000067805Danio rerio
 GGCXENSG00000115486Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007782  Vitamin K-dependent gamma-carboxylase
 IPR011020  HTTM
 IPR011051  RmlC-like cupin domain superfamily
 IPR014710  RmlC-like jelly roll fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0017187 peptidyl-glutamic acid carboxylation IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008488 gamma-glutamyl carboxylase activity IEA
 molecular_functionGO:0016829 lyase activity IEA


Pathways (from Reactome)
Pathway description
Gamma-carboxylation of protein precursors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ggcxtm1Sino/Ggcxtm1Sino,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ggcxtm1Sino Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ggcxtm1Sino/Ggcxtm1Sino,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ggcxtm1Sino Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ggcxtm1Sino/Ggcxtm1Sino,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ggcxtm1Sino Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0004245 genital hemorrhage "bleeding into the genitals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ggcxtm1Sino/Ggcxtm1Sino,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ggcxtm1Sino Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0004898 uterine hemorrhage "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ggcxtm1Sino/Ggcxtm1Sino,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ggcxtm1Sino Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ggcxtm1Sino/Ggcxtm1Sino,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ggcxtm1Sino Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ggcxtm1Sino/Ggcxtm1Sino,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ggcxtm1Sino Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Thtm1Srt/Thtm1Srt,Tyrc/Tyrc
Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

 MP:0020215 impaired blood coagulation "impaired ability of the blood to clot" [GOC:NV]
Show

Allelic Composition: Ggcxtm1Sino/Ggcxtm1Sino,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ggcxtm1Sino Speer6-ps1Tg(Alb-cre)21Mgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022912 Pros1 / Q08761 / protein S (alpha) / P07225* / protein S*  / reaction
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / reaction
 ENSMUSG00000031443 F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*  / reaction
 ENSMUSG00000031444 F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*  / reaction
 ENSMUSG00000074483 Bglap / P86546 / Osteocalcin / P02818* / bone gamma-carboxyglutamate protein*  / reaction
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000074486 Bglap2 / P86547 / Osteocalcin-2 / BGLAP* / P02818* / bone gamma-carboxyglutamate protein*  / reaction
 ENSMUSG00000074489 Bglap3 / P54615 / Osteocalcin-related protein / BGLAP* / P02818* / bone gamma-carboxyglutamate protein*  / reaction
 ENSMUSG00000031445 Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr