Manteia - Molecule gene

ENSMUSG00000031445

Mus musculus

Features

Gene ID:	ENSMUSG00000031445

Biological name :	Proz

Synonyms :	protein Z, vitamin K-dependent plasma glycoprotein / Proz / Q9CQW3

Possible biological names infered from orthology :	P22891

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	A1.1
Gene start:	13060914
Gene end:	13076026

Corresponding Affymetrix probe sets:	10570308 (MoGene1.0st) 1431721_a_at (Mouse Genome 430 2.0 Array) 1450201_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000033822 Ensembl peptide - ENSMUSP00000147328 Ensembl peptide - ENSMUSP00000147733 NCBI entrez gene - 66901 See in Manteia. MGI - MGI:1860488 RefSeq - XM_006508859 RefSeq - NM_001357219 RefSeq - NM_025834 RefSeq - XM_006508856 RefSeq - XM_006508858 RefSeq Peptide - NP_001344148 RefSeq Peptide - NP_080110 swissprot - Q8CI01 swissprot - Q9CQW3 swissprot - A0A1B0GR07 Ensembl - ENSMUSG00000031445

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
proza	ENSDARG00000037783	Danio rerio
prozb	ENSDARG00000076900	Danio rerio
PROZ	ENSGALG00000016832	Gallus gallus
PROZ	ENSG00000126231	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*	ENSMUSG00000031138	34
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*	ENSMUSG00000031444	33
Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...	ENSMUSG00000024386	31
F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*	ENSMUSG00000031443	30
C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*	ENSMUSG00000055172	24
Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...	ENSMUSG00000028979	23
Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*	ENSMUSG00000022887	23
C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*	ENSMUSG00000098470	23
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*	ENSMUSG00000038521	21
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*	ENSMUSG00000079343	21
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*	ENSMUSG00000027188	20
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*	ENSMUSG00000038527	17
Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*	ENSMUSG00000031722	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR000152	EGF-type aspartate/asparagine hydroxylation site
IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742	EGF-like domain
IPR001254	Serine proteases, trypsin domain
IPR001881	EGF-like calcium-binding domain
IPR009003	Peptidase S1, PA clan
IPR012224	Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR013032	EGF-like, conserved site
IPR017857	Coagulation factor-like, Gla domain superfamily
IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006508	proteolysis	IEA
biological_process	GO:0007596	blood coagulation	IMP
biological_process	GO:0007599	hemostasis	IEA
biological_process	GO:0030195	negative regulation of blood coagulation	IBA
cellular_component	GO:0005576	extracellular region	IDA
cellular_component	GO:0005615	extracellular space	IBA
molecular_function	GO:0004252	serine-type endopeptidase activity	IBA
molecular_function	GO:0005509	calcium ion binding	TAS

Pathways (from Reactome)

Pathway description

Gamma-carboxylation of protein precursors

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: F5^tm2Dgi/F5^tm2Dgi,Proz^tm1Gjb/Proz^tm1Gjb Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mstn^tm1Sjl/Mstn^tm1Sjl Genetic Background: B6N.129-Mstn^tm1Sjl Allelic Composition: F5^tm2Dgi/F5^tm2Dgi,Proz^tm1Gjb/Proz^tm1Gjb Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: F5^tm2Dgi/F5^tm2Dgi,Proz^tm1Gjb/Proz⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: F5^tm2Dgi/F5^tm2Dgi,Proz^tm1Gjb/Proz⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0005048	thrombosis	"formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: F5^tm2Dgi/F5^tm2Dgi,Proz^tm1Gjb/Proz^tm1Gjb Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: F5^tm2Dgi/F5^tm2Dgi,Proz^tm1Gjb/Proz⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0006066	decreased clearance of atrial thrombosis	"slower removal of a thrombus from the atria of the heart" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Atp7a^Mo-pew/Y Genetic Background: CBA/J-Atp7a^Mo-pew
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atp7a^Mo-pew/Y Genetic Background: CBA/J-Atp7a^Mo-pew

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000053460	Ggcx / Q9QYC7 / Vitamin K-dependent gamma-carboxylase / P38435* / gamma-glutamyl carboxylase*	/ reaction
ENSMUSG00000030530	Furin / P23188 / P09958* / furin, paired basic amino acid cleaving enzyme*	/ reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr