ENSG00000126231


Homo sapiens

Features
Gene ID: ENSG00000126231
  
Biological name :PROZ
  
Synonyms : P22891 / protein Z, vitamin K dependent plasma glycoprotein / PROZ
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 113158654
Gene end: 113172383
  
Corresponding Affymetrix probe sets: 208034_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000344458
Ensembl peptide - ENSP00000364697
NCBI entrez gene - 8858     See in Manteia.
OMIM - 176895
RefSeq - XM_017020813
RefSeq - NM_001256134
RefSeq - NM_003891
RefSeq - XM_017020812
RefSeq Peptide - NP_001243063
RefSeq Peptide - NP_003882
swissprot - P22891
Ensembl - ENSG00000126231
  
Related genetic diseases (OMIM): 614024 - [Protein Z deficiency], 614024
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prozaENSDARG00000037783Danio rerio
 prozbENSDARG00000076900Danio rerio
 PROZENSGALG00000016832Gallus gallus
 ProzENSMUSG00000031445Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F9 / P00740 / coagulation factor IXENSG0000010198132
F10 / P00742 / coagulation factor XENSG0000012621832
PROC / P04070 / protein C, inactivator of coagulation factors Va and VIIIaENSG0000011571831
F7 / P08709 / coagulation factor VIIENSG0000005759330
C1R / P00736 / complement C1rENSG0000015940323
C1S / P09871 / complement C1sENSG0000018232621
MASP1 / P48740 / mannan binding lectin serine peptidase 1ENSG0000012724121
MASP2 / O00187 / mannan binding lectin serine peptidase 2ENSG0000000972421
PAMR1 / Q6UXH9 / peptidase domain containing associated with muscle regeneration 1ENSG0000014909020
C1RL / Q9NZP8 / complement C1r subcomponent likeENSG0000013917816
HP / P00738 / haptoglobinENSG0000025701713
HPR / P00739 / haptoglobin-related proteinENSG0000026170112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR012224  Peptidase S1A, coagulation factor VII/IX/X/C/Z
 IPR013032  EGF-like, conserved site
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006465 signal peptide processing TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0017187 peptidyl-glutamic acid carboxylation TAS
 biological_processGO:0030195 negative regulation of blood coagulation IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115486 GGCX / P38435 / gamma-glutamyl carboxylase  / reaction
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction






 

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