ENSG00000257017


Homo sapiens

Features
Gene ID: ENSG00000257017
  
Biological name :HP
  
Synonyms : haptoglobin / HP / P00738
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.2
Gene start: 72054592
Gene end: 72061055
  
Corresponding Affymetrix probe sets: 206697_s_at (Human Genome U133 Plus 2.0 Array)   208470_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463491
Ensembl peptide - ENSP00000463755
Ensembl peptide - ENSP00000478279
Ensembl peptide - ENSP00000464070
Ensembl peptide - ENSP00000228226
Ensembl peptide - ENSP00000348170
Ensembl peptide - ENSP00000350406
Ensembl peptide - ENSP00000381199
Ensembl peptide - ENSP00000454413
Ensembl peptide - ENSP00000454966
Ensembl peptide - ENSP00000456503
Ensembl peptide - ENSP00000457629
Ensembl peptide - ENSP00000461999
Ensembl peptide - ENSP00000462662
NCBI entrez gene - 3240     See in Manteia.
OMIM - 140100
RefSeq - NM_001318138
RefSeq - NM_005143
RefSeq - NM_001126102
RefSeq Peptide - NP_001119574
RefSeq Peptide - NP_001305067
RefSeq Peptide - NP_005134
swissprot - J3KSV1
swissprot - J3QLC9
swissprot - J3QQI8
swissprot - J3QR68
swissprot - A0A0C4DGL8
swissprot - P00738
swissprot - A0A087WU08
swissprot - H0Y300
swissprot - H3BMJ7
swissprot - H3BS21
swissprot - J3KRH2
Ensembl - ENSG00000257017
  
Related genetic diseases (OMIM): 614081 - [Anhaptoglobinemia], 614081
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpENSDARG00000051890Danio rerio
 HpENSMUSG00000031722Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HPR / P00739 / haptoglobin-related proteinENSG0000026170178
C1R / P00736 / complement C1rENSG0000015940330
C1S / P09871 / complement C1sENSG0000018232630
MASP1 / P48740 / mannan binding lectin serine peptidase 1ENSG0000012724129
MASP2 / O00187 / mannan binding lectin serine peptidase 2ENSG0000000972427
C1RL / Q9NZP8 / complement C1r subcomponent likeENSG0000013917821
F9 / P00740 / coagulation factor IXENSG0000010198120
F10 / P00742 / coagulation factor XENSG0000012621820
F7 / P08709 / coagulation factor VIIENSG0000005759319
PAMR1 / Q6UXH9 / peptidase domain containing associated with muscle regeneration 1ENSG0000014909018
PROC / P04070 / protein C, inactivator of coagulation factors Va and VIIIaENSG0000011571818
PROZ / P22891 / protein Z, vitamin K dependent plasma glycoproteinENSG0000012623113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR008292  Haptoglobin
 IPR009003  Peptidase S1, PA clan
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006952 defense response TAS
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0010942 positive regulation of cell death IDA
 biological_processGO:0042542 response to hydrogen peroxide IDA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0051354 negative regulation of oxidoreductase activity IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2000296 negative regulation of hydrogen peroxide catabolic process IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031838 haptoglobin-hemoglobin complex IDA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071682 endocytic vesicle lumen TAS
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0030492 hemoglobin binding IDA


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000257017 HP / P00738 / haptoglobin  / complex
 ENSG00000177575 CD163 / Q86VB7 / CD163 molecule  / complex / reaction
 ENSG00000188536 HBA2 / P69905 / hemoglobin subunit alpha 2  / reaction / complex
 ENSG00000244734 HBB / P68871 / hemoglobin subunit beta  / reaction / complex






 

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