ENSMUSG00000031722


Mus musculus

Features
Gene ID: ENSMUSG00000031722
  
Biological name :Hp
  
Synonyms : Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / Hp / Q61646
  
Possible biological names infered from orthology : haptoglobin / haptoglobin-related protein / HPR / P00738 / P00739
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 109575128
Gene end: 109579172
  
Corresponding Affymetrix probe sets: 10581605 (MoGene1.0st)   1448881_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074436
NCBI entrez gene - 15439     See in Manteia.
MGI - MGI:96211
RefSeq - NM_017370
RefSeq Peptide - NP_059066
swissprot - Q3UBS3
swissprot - Q61646
Ensembl - ENSMUSG00000031722
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpENSDARG00000051890Danio rerio
 HPENSG00000257017Homo sapiens
 HPRENSG00000261701Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C1rb / Q8CFG9 / Complement C1r-B subcomponent Complement C1r-B subcomponent heavy chain Complement C1r-B subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000009847032
C1ra / Q8CG16 / Complement C1r-A subcomponent Complement C1r-A subcomponent heavy chain Complement C1r-A subcomponent light chain / C1R* / P00736* / complement C1r*ENSMUSG0000005517231
C1s1 / complement component 1, s subcomponent 1 / C1S* / P09871* / complement C1s*ENSMUSG0000003852131
C1s2 / Q8CFG8 / complement component 1, s subcomponent 2 / C1S* / P09871* / complement C1s*ENSMUSG0000007934330
Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...ENSMUSG0000002897930
Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*ENSMUSG0000002288729
C1rl / Q3UZ09 / Complement C1r subcomponent-like protein / Q9NZP8* / complement C1r subcomponent like*ENSMUSG0000003852724
F10 / O88947 / Coagulation factor X Factor X light chain Factor X heavy chain Activated factor Xa heavy chain / P00742* / coagulation factor X*ENSMUSG0000003144423
F7 / P70375 / Coagulation factor VII Factor VII light chain Factor VII heavy chain / P08709* / coagulation factor VII*ENSMUSG0000003144321
Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...ENSMUSG0000002438620
F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*ENSMUSG0000003113820
Pamr1 / Q8BU25 / Inactive serine protease PAMR1 / Q6UXH9* / peptidase domain containing associated with muscle regeneration 1*ENSMUSG0000002718820
Proz / Q9CQW3 / protein Z, vitamin K-dependent plasma glycoprotein / P22891*ENSMUSG0000003144515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR008292  Haptoglobin
 IPR009003  Peptidase S1, PA clan
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0010942 positive regulation of cell death ISO
 biological_processGO:0042542 response to hydrogen peroxide ISO
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0051354 negative regulation of oxidoreductase activity ISO
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2000296 negative regulation of hydrogen peroxide catabolic process ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0031838 haptoglobin-hemoglobin complex ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0030492 hemoglobin binding ISO


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000332 hemoglobinemia "the presence of free hemoglobin in the blood plasma, an indication of significant intravascular hemolysis" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:82330]
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Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hptm1Alev/Hptm1Alev
Genetic Background: involves: 129

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Hptm1Skl/Hptm1Skl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hptm1Alev/Hptm1Alev
Genetic Background: involves: 129

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Del(1)1Brk/Steap3tm1.1Mdf
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000008845 Cd163 / Q2VLH6 / Scavenger receptor cysteine-rich type 1 protein M130 Soluble CD163 / Q86VB7* / CD163 molecule*  / reaction / complex
 ENSMUSG00000069919 Hba-a1 / hemoglobin alpha, adult chain 1 / HBA2* / HBA1* / P69905* / hemoglobin subunit alpha 1* / hemoglobin subunit alpha 2*  / complex / reaction
 ENSMUSG00000073940 Hbb-bt / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*  / complex / reaction
 ENSMUSG00000031722 Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*  / complex






 

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