ENSMUSG00000008845


Mus musculus

Features
Gene ID: ENSMUSG00000008845
  
Biological name :Cd163
  
Synonyms : Cd163 / Q2VLH6 / Scavenger receptor cysteine-rich type 1 protein M130 Soluble CD163
  
Possible biological names infered from orthology : CD163 molecule / Q86VB7
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F2
Gene start: 124304656
Gene end: 124330527
  
Corresponding Affymetrix probe sets: 10541644 (MoGene1.0st)   1419144_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032234
Ensembl peptide - ENSMUSP00000108160
NCBI entrez gene - 93671     See in Manteia.
MGI - MGI:2135946
RefSeq - XM_017321840
RefSeq - NM_001170395
RefSeq - NM_053094
RefSeq - XM_006506800
RefSeq Peptide - NP_444324
RefSeq Peptide - NP_001163866
swissprot - Q2VLH6
swissprot - B7ZMW6
Ensembl - ENSMUSG00000008845
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX784029.3ENSDARG00000096156Danio rerio
 BX784029.4ENSDARG00000096184Danio rerio
 si:ch211-161n3.3ENSDARG00000092989Danio rerio
 si:ch211-161n3.4ENSDARG00000045752Danio rerio
 si:ch211-161n3.5ENSDARG00000095981Danio rerio
 si:dkey-21h14.10ENSDARG00000096187Danio rerio
 si:dkey-21h14.12ENSDARG00000094603Danio rerio
 si:dkey-21h14.8ENSDARG00000096083Danio rerio
 si:dkey-21h14.9ENSDARG00000096153Danio rerio
 ENSGALG00000046256Gallus gallus
 CD163ENSG00000177575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
5830411N06Rik / RIKEN cDNA 5830411N06 gene / Q4G0T1* / SCART1* / scavenger receptor family member expressed on T cells 1*ENSMUSG0000005467233
Cd163l1 / CD163 molecule-like 1 / Q4G0T1* / SCART1* / scavenger receptor family member expressed on T cells 1*ENSMUSG0000002546132
Dmbt1 / Mus musculus deleted in malignant brain tumors 1 (Dmbt1), transcript variant 1, mRNA. / Q9UGM3* / deleted in malignant brain tumors 1*ENSMUSG0000004751731
Ssc5d / Q8BV57 / Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D / A1L4H1* / scavenger receptor cysteine rich family member with 5 domains*ENSMUSG0000003527919
Ssc4d / A1L0T3 / scavenger receptor cysteine rich family, 4 domains / Q8WTU2* / scavenger receptor cysteine rich family member with 4 domains*ENSMUSG0000002969918
Q8BZE1 / 5430419D17Rik / Putative DMBT1-like protein ENSMUSG0000000620415
O08762 / Prss12 / protease, serine 12 neurotrypsin (motopsin) / P56730* / serine protease 12*ENSMUSG0000002797815
Cd5l / Q9QWK4 / CD5 antigen-like / O43866* / CD5 molecule like*ENSMUSG0000001585411


Protein motifs (from Interpro)
Interpro ID Name
 IPR001190  SRCR domain
 IPR017448  SRCR-like domain
 IPR036772  SRCR-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005044 scavenger receptor activity ISO


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0002281 abnormal respiratory mucosa goblet cell morphology "structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flcntm1Baba/Flcntm1Baba,Fnip1tm1.1Baba/Fnip1tm1.1Baba,Fnip2tm1.1Lss/Fnip2tm1.1Lss,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * ICR

 MP:0003060 increased aerobic running capacity "greater ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0003082 abnormal gastrocnemius morphology "anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0009410 abnormal skeletal muscle satellite cell proliferation "anomaly in the ability of unfused cells in skeltal muscle to undergo expansion by cell division, usually triggered by injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0010098 abnormal retinal blood vessel pattern "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0013237 abnormal skeletal muscle regeneration "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031722 Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*  / complex / reaction
 ENSMUSG00000069919 Hba-a1 / hemoglobin alpha, adult chain 1 / HBA2* / HBA1* / P69905* / hemoglobin subunit alpha 1* / hemoglobin subunit alpha 2*  / reaction / complex
 ENSMUSG00000073940 Hbb-bt / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*  / reaction / complex






 

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