ENSMUSG00000069919


Mus musculus

Features
Gene ID: ENSMUSG00000069919
  
Biological name :Hba-a1
  
Synonyms : Hba-a1 / hemoglobin alpha, adult chain 1
  
Possible biological names infered from orthology : HBA1 / HBA2 / hemoglobin subunit alpha 1 / hemoglobin subunit alpha 2 / P69905
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 32283511
Gene end: 32284465
  
Corresponding Affymetrix probe sets: 10375051 (MoGene1.0st)   10375058 (MoGene1.0st)   1417714_x_at (Mouse Genome 430 2.0 Array)   1428361_x_at (Mouse Genome 430 2.0 Array)   1452757_s_at (Mouse Genome 430 2.0 Array)   1453574_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090897
NCBI entrez gene - 15122     See in Manteia.
MGI - MGI:96015
RefSeq - NM_008218
RefSeq Peptide - NP_032244
swissprot - Q91VB8
Ensembl - ENSMUSG00000069919
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HBA1ENSGALG00000043234Gallus gallus
 HBA1ENSG00000206172Homo sapiens
 HBA2ENSG00000188536Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hba-a2 / hemoglobin alpha, adult chain 2 / HBA2* / HBA1* / P69905* / hemoglobin subunit alpha 1* / hemoglobin subunit alpha 2*ENSMUSG00000069917100
Hbq1b / HBQ1* / P09105* / hemoglobin subunit theta 1*ENSMUSG0000007306362
Hbq1a / HBQ1* / P09105* / hemoglobin subunit theta 1*ENSMUSG0000002029554
Hba-x / P06467 / hemoglobin X, alpha-like embryonic chain in Hba complex / HBZ* / P02008* / hemoglobin subunit zeta*ENSMUSG0000005560954
Hbb-bs / Mus musculus hemoglobin, beta adult major chain (Hbb-b1), mRNA. / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*ENSMUSG0000005230544
Hbb-bt / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*ENSMUSG0000007394044
Hbb-y / hemoglobin subunit epsilon 1 / HBE1* / P02100*ENSMUSG0000005218743
P04444 / Hbb-bh1 / hemoglobin Z, beta-like embryonic chain / HBG2* / HBG1* / P69892* / P69891* / AC104389.5* / hemoglobin subunit gamma 2* / hemoglobin subunit gamma 1*ENSMUSG0000005221737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000971  Globin
 IPR002338  Haemoglobin, alpha-type
 IPR002339  Haemoglobin, pi
 IPR009050  Globin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0015671 oxygen transport IEA
 biological_processGO:0048821 erythrocyte development IGI
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005833 hemoglobin complex ISO
 cellular_componentGO:0022627 cytosolic small ribosomal subunit ISO
 cellular_componentGO:0031838 haptoglobin-hemoglobin complex ISO
 molecular_functionGO:0004601 peroxidase activity ISO
 molecular_functionGO:0005344 oxygen carrier activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0019825 oxygen binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0031720 haptoglobin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000226 abnormal mean corpuscular volume "deviation from the norm for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Hba-a1tm1Led/Hba-a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hba-a1tm1Led/Hba-a1+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Led/Hba-a1tm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Led/Hba-a1+,Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1tm1Ywk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1tm1Ywk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001588 hemoglobin abnormalities "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Hba-a1tm1Led/Hba-a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hba-a1tm1Led/Hba-a1+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Led/Hba-a1tm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Led/Hba-a1+,Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Ywk/Hba-a1tm1Ywk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001589 abnormal mean corpuscular hemoglobin "anomalies in the average levels of hemoglobin contained in an erythrocyte" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Hba-a1tm1Led/Hba-a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hba-a1tm1Led/Hba-a1+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Led/Hba-a1tm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Led/Hba-a1+,Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002319 hyperoxia "elevated concentration of O2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Hba-a1tm1Led/Hba-a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hba-a1tm1Led/Hba-a1tm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1tm1Ywk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1tm1Ywk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1tm1Ywk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003060 increased aerobic running capacity "greater ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * CD-1)

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hba-a1tm1Led/Hba-a1tm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-a1tm1Led/Hba-a1+,Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Ywk/Hba-a1tm1Ywk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0010175 leptocytosis "the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull s-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Hba-a1tm1Shs/Hba-a1+
Genetic Background: involves: C57BL/6CrSlc

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Hba-a1tm1Ywk/Hbath-J
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026456 Cyb5r1 / Q9DB73 / cytochrome b5 reductase 1 / Q9UHQ9*  / reaction
 ENSMUSG00000008845 Cd163 / Q2VLH6 / Scavenger receptor cysteine-rich type 1 protein M130 Soluble CD163 / Q86VB7* / CD163 molecule*  / complex / reaction
 ENSMUSG00000028621 B1AS42 / Cyb5rl / NADH-cytochrome b5 reductase-like / Q6IPT4* / AL357673.1* / cytochrome b5 reductase like*  / reaction
 ENSMUSG00000030895 Hpx / Q91X72 / Hemopexin / P02790*  / reaction
 ENSMUSG00000048065 Cyb5r2 / Q3KNK3 / NADH-cytochrome b5 reductase 2 / Q6BCY4* / cytochrome b5 reductase 2*  / reaction
 ENSMUSG00000031722 Hp / Q61646 / Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain / HPR* / P00738* / P00739* / haptoglobin* / haptoglobin-related protein*  / complex / reaction
 ENSMUSG00000069919 Hba-a1 / hemoglobin alpha, adult chain 1 / HBA2* / HBA1* / P69905* / hemoglobin subunit alpha 1* / hemoglobin subunit alpha 2*  / complex / reaction
 ENSMUSG00000073940 Hbb-bt / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*  / complex / reaction
 ENSMUSG00000032872 Cyb5r4 / Q3TDX8 / Cytochrome b5 reductase 4 / Q7L1T6*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr