ENSMUSG00000032872


Mus musculus

Features
Gene ID: ENSMUSG00000032872
  
Biological name :Cyb5r4
  
Synonyms : Cyb5r4 / Cytochrome b5 reductase 4 / Q3TDX8
  
Possible biological names infered from orthology : Q7L1T6
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.1
Gene start: 87022014
Gene end: 87077774
  
Corresponding Affymetrix probe sets: 10511725 (MoGene1.0st)   10587627 (MoGene1.0st)   1426307_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126119
Ensembl peptide - ENSMUSP00000133918
NCBI entrez gene - 266690     See in Manteia.
MGI - MGI:2386848
RefSeq - XM_017313397
RefSeq - NM_024195
RefSeq - XM_006511199
RefSeq - XM_006511200
RefSeq Peptide - NP_077157
swissprot - G3UY26
swissprot - Q3TDX8
Ensembl - ENSMUSG00000032872
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyb5r4ENSDARG00000020898Danio rerio
 ENSGALG00000015843Gallus gallus
 CYB5R4ENSG00000065615Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyb5r1 / Q9DB73 / cytochrome b5 reductase 1 / Q9UHQ9*ENSMUSG0000002645616
Cyb5r2 / Q3KNK3 / NADH-cytochrome b5 reductase 2 / Q6BCY4* / cytochrome b5 reductase 2*ENSMUSG0000004806515
Cyb5r3 / Q9DCN2 / NADH-cytochrome b5 reductase 3 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form / P00387* / cytochrome b5 reductase 3*ENSMUSG0000001804214


Protein motifs (from Interpro)
Interpro ID Name
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001834  NADH:cytochrome b5 reductase (CBR)
 IPR007052  CS domain
 IPR008333  Oxidoreductase, FAD-binding domain
 IPR008978  HSP20-like chaperone
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR018506  Cytochrome b5, heme-binding site
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006091 generation of precursor metabolites and energy IEA
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0042168 heme metabolic process ISO
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046677 response to antibiotic IMP
 biological_processGO:0048468 cell development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016174 NAD(P)H oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IEA
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Erythrocytes take up carbon dioxide and release oxygen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000069919 Hba-a1 / hemoglobin alpha, adult chain 1 / HBA2* / HBA1* / P69905* / hemoglobin subunit alpha 1* / hemoglobin subunit alpha 2*  / reaction
 ENSMUSG00000073940 Hbb-bt / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*  / reaction






 

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