ENSMUSG00000018042


Mus musculus

Features
Gene ID: ENSMUSG00000018042
  
Biological name :Cyb5r3
  
Synonyms : Cyb5r3 / NADH-cytochrome b5 reductase 3 NADH-cytochrome b5 reductase 3 membrane-bound form NADH-cytochrome b5 reductase 3 soluble form / Q9DCN2
  
Possible biological names infered from orthology : cytochrome b5 reductase 3 / P00387
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 83153494
Gene end: 83172592
  
Corresponding Affymetrix probe sets: 10430956 (MoGene1.0st)   1422185_a_at (Mouse Genome 430 2.0 Array)   1422186_s_at (Mouse Genome 430 2.0 Array)   1425329_a_at (Mouse Genome 430 2.0 Array)   1430734_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125636
Ensembl peptide - ENSMUSP00000018186
Ensembl peptide - ENSMUSP00000124062
NCBI entrez gene - 109754     See in Manteia.
MGI - MGI:94893
RefSeq - XM_006520282
RefSeq - XM_006520283
RefSeq - NM_029787
RefSeq Peptide - NP_084063
swissprot - Q9DCN2
swissprot - F2Z456
swissprot - A0A0A0MQM3
Ensembl - ENSMUSG00000018042
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyb5r3ENSDARG00000005891Danio rerio
 CYB5R3ENSGALG00000014122Gallus gallus
 CYB5R3ENSG00000100243Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyb5r1 / Q9DB73 / cytochrome b5 reductase 1 / Q9UHQ9*ENSMUSG0000002645659
Cyb5r2 / Q3KNK3 / NADH-cytochrome b5 reductase 2 / Q6BCY4* / cytochrome b5 reductase 2*ENSMUSG0000004806554
Cyb5r4 / Q3TDX8 / Cytochrome b5 reductase 4 / Q7L1T6*ENSMUSG0000003287225


Protein motifs (from Interpro)
Interpro ID Name
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR001834  NADH:cytochrome b5 reductase (CBR)
 IPR008333  Oxidoreductase, FAD-binding domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016208 AMP binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Vitamin C (ascorbate) metabolism
Phase I - Functionalization of compounds
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000073481 Marc2 / Q922Q1 / Mitochondrial amidoxime reducing component 2 / Q969Z3*  / complex
 ENSMUSG00000024646 Cyb5a / P56395 / Cytochrome b5 / P00167* / cytochrome b5 type A*  / reaction
 ENSMUSG00000026621 Marc1 / Q9CW42 / Mitochondrial amidoxime-reducing component 1 / Q5VT66*  / complex
 ENSMUSG00000031924 Cyb5b / Q9CQX2 / Cytochrome b5 type B / O43169*  / complex






 

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