ENSG00000065615


Homo sapiens

Features
Gene ID: ENSG00000065615
  
Biological name :CYB5R4
  
Synonyms : CYB5R4 / cytochrome b5 reductase 4 / Q7L1T6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q14.2
Gene start: 83859643
Gene end: 83967424
  
Corresponding Affymetrix probe sets: 219079_at (Human Genome U133 Plus 2.0 Array)   240020_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358693
Ensembl peptide - ENSP00000358695
NCBI entrez gene - 51167     See in Manteia.
OMIM - 608343
RefSeq - NM_016230
RefSeq Peptide - NP_057314
swissprot - A0A0A0MRM6
swissprot - Q7L1T6
Ensembl - ENSG00000065615
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyb5r4ENSDARG00000020898Danio rerio
 ENSGALG00000015843Gallus gallus
 Cyb5r4ENSMUSG00000032872Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYB5R3 / P00387 / cytochrome b5 reductase 3ENSG0000010024316
CYB5R1 / Q9UHQ9 / cytochrome b5 reductase 1ENSG0000015934816
CYB5R2 / Q6BCY4 / cytochrome b5 reductase 2ENSG0000016639414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001834  NADH:cytochrome b5 reductase (CBR)
 IPR007052  CS domain
 IPR008333  Oxidoreductase, FAD-binding domain
 IPR008978  HSP20-like chaperone
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR018506  Cytochrome b5, heme-binding site
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003032 detection of oxygen NAS
 biological_processGO:0006091 generation of precursor metabolites and energy IDA
 biological_processGO:0006801 superoxide metabolic process IDA
 biological_processGO:0015701 bicarbonate transport TAS
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0055114 oxidation-reduction process IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H TAS
 molecular_functionGO:0016174 NAD(P)H oxidase activity IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IDA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Erythrocytes take up carbon dioxide and release oxygen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000244734 HBB / P68871 / hemoglobin subunit beta  / reaction
 ENSG00000188536 HBA2 / P69905 / hemoglobin subunit alpha 2  / reaction






 

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