ENSG00000159348


Homo sapiens

Features
Gene ID: ENSG00000159348
  
Biological name :CYB5R1
  
Synonyms : CYB5R1 / cytochrome b5 reductase 1 / Q9UHQ9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 202961869
Gene end: 202967280
  
Corresponding Affymetrix probe sets: 1560043_at (Human Genome U133 Plus 2.0 Array)   202263_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356218
Ensembl peptide - ENSP00000396382
NCBI entrez gene - 51706     See in Manteia.
OMIM - 608341
RefSeq - NM_016243
RefSeq Peptide - NP_057327
swissprot - Q9UHQ9
swissprot - H7C0R7
Ensembl - ENSG00000159348
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyb5r1ENSDARG00000018966Danio rerio
 Cyb5r1ENSMUSG00000026456Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYB5R3 / P00387 / cytochrome b5 reductase 3ENSG0000010024359
CYB5R2 / Q6BCY4 / cytochrome b5 reductase 2ENSG0000016639452
CYB5R4 / Q7L1T6 / cytochrome b5 reductase 4ENSG0000006561527


Protein motifs (from Interpro)
Interpro ID Name
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR001834  NADH:cytochrome b5 reductase (CBR)
 IPR008333  Oxidoreductase, FAD-binding domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0015701 bicarbonate transport TAS
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031092 platelet alpha granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Erythrocytes take up carbon dioxide and release oxygen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000244734 HBB / P68871 / hemoglobin subunit beta  / reaction
 ENSG00000188536 HBA2 / P69905 / hemoglobin subunit alpha 2  / reaction






 

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