ENSG00000166394


Homo sapiens

Features
Gene ID: ENSG00000166394
  
Biological name :CYB5R2
  
Synonyms : CYB5R2 / cytochrome b5 reductase 2 / Q6BCY4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 7665100
Gene end: 7677222
  
Corresponding Affymetrix probe sets: 220230_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432482
Ensembl peptide - ENSP00000392777
Ensembl peptide - ENSP00000433856
Ensembl peptide - ENSP00000437041
Ensembl peptide - ENSP00000435916
Ensembl peptide - ENSP00000434969
Ensembl peptide - ENSP00000299498
NCBI entrez gene - 51700     See in Manteia.
OMIM - 608342
RefSeq - XM_017017922
RefSeq - NM_001302827
RefSeq - NM_016229
RefSeq - XM_005252975
RefSeq - XM_006718251
RefSeq - XM_011520184
RefSeq - XM_011520185
RefSeq - XM_017017920
RefSeq - XM_017017921
RefSeq - NM_001302826
RefSeq Peptide - NP_057313
RefSeq Peptide - NP_001289755
RefSeq Peptide - NP_001289756
swissprot - E9PRM4
swissprot - E9PIV9
swissprot - Q6BCY4
swissprot - E9PQW2
swissprot - E9PMI2
Ensembl - ENSG00000166394
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyb5r2ENSDARG00000051925Danio rerio
 CYB5R2ENSGALG00000032372Gallus gallus
 Cyb5r2ENSMUSG00000048065Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYB5R3 / P00387 / cytochrome b5 reductase 3ENSG0000010024359
CYB5R1 / Q9UHQ9 / cytochrome b5 reductase 1ENSG0000015934858
CYB5R4 / Q7L1T6 / cytochrome b5 reductase 4ENSG0000006561526


Protein motifs (from Interpro)
Interpro ID Name
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR001834  NADH:cytochrome b5 reductase (CBR)
 IPR008333  Oxidoreductase, FAD-binding domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0015701 bicarbonate transport TAS
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Erythrocytes take up carbon dioxide and release oxygen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188536 HBA2 / P69905 / hemoglobin subunit alpha 2  / reaction
 ENSG00000244734 HBB / P68871 / hemoglobin subunit beta  / reaction






 

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