ENSMUSG00000055609


Mus musculus

Features
Gene ID: ENSMUSG00000055609
  
Biological name :Hba-x
  
Synonyms : Hba-x / hemoglobin X, alpha-like embryonic chain in Hba complex / P06467
  
Possible biological names infered from orthology : HBZ / hemoglobin subunit zeta / P02008
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 32276400
Gene end: 32278116
  
Corresponding Affymetrix probe sets: 10375046 (MoGene1.0st)   1448716_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118167
Ensembl peptide - ENSMUSP00000020531
NCBI entrez gene - 15126     See in Manteia.
MGI - MGI:96019
RefSeq - NM_010405
RefSeq Peptide - NP_034535
swissprot - A7M7S6
swissprot - P06467
swissprot - Q78PA4
Ensembl - ENSMUSG00000055609
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbaa1ENSDARG00000097011Danio rerio
 hbaa2ENSDARG00000069735Danio rerio
 hbae1ENSDARG00000089475Danio rerio
 hbae1ENSDARG00000088330Danio rerio
 hbae1.3ENSDARG00000089124Danio rerio
 hbae3ENSDARG00000079305Danio rerio
 hbae5ENSDARG00000045142Danio rerio
 si:ch211-5k11.8ENSDARG00000079078Danio rerio
 HBZENSGALG00000023740Gallus gallus
 HBZENSG00000130656Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hba-a1 / hemoglobin alpha, adult chain 1 / HBA2* / HBA1* / P69905* / hemoglobin subunit alpha 1* / hemoglobin subunit alpha 2*ENSMUSG0000006991954
Hba-a2 / hemoglobin alpha, adult chain 2 / HBA2* / HBA1* / P69905* / hemoglobin subunit alpha 1* / hemoglobin subunit alpha 2*ENSMUSG0000006991754
Hbq1b / HBQ1* / P09105* / hemoglobin subunit theta 1*ENSMUSG0000007306345
P04444 / Hbb-bh1 / hemoglobin Z, beta-like embryonic chain / HBG2* / HBG1* / P69892* / P69891* / AC104389.5* / hemoglobin subunit gamma 2* / hemoglobin subunit gamma 1*ENSMUSG0000005221742
Hbb-y / hemoglobin subunit epsilon 1 / HBE1* / P02100*ENSMUSG0000005218742
Hbq1a / HBQ1* / P09105* / hemoglobin subunit theta 1*ENSMUSG0000002029540
Hbb-bt / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*ENSMUSG0000007394037
Hbb-bs / Mus musculus hemoglobin, beta adult major chain (Hbb-b1), mRNA. / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*ENSMUSG0000005230537


Protein motifs (from Interpro)
Interpro ID Name
 IPR000971  Globin
 IPR002338  Haemoglobin, alpha-type
 IPR002340  Haemoglobin, zeta
 IPR009050  Globin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0015671 oxygen transport IEA
 biological_processGO:0043249 erythrocyte maturation IMP
 cellular_componentGO:0005833 hemoglobin complex IEA
 molecular_functionGO:0005344 oxygen carrier activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0019825 oxygen binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000226 abnormal mean corpuscular volume "deviation from the norm for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hba-a1tm1Led/Hba-a1tm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001588 hemoglobin abnormalities "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Led/Hba-a1+,Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001589 abnormal mean corpuscular hemoglobin "anomalies in the average levels of hemoglobin contained in an erythrocyte" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-a1tm1Led/Hba-a1+,Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hba-a1tm1Led/Hba-a1+,Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hba-a1tm1Led/Hba-a1+,Hba-xtm1Led/Hba-x+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hba-xtm1Led/Hba-xtm1Led
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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