ENSMUSG00000030895


Mus musculus

Features
Gene ID: ENSMUSG00000030895
  
Biological name :Hpx
  
Synonyms : Hemopexin / Hpx / Q91X72
  
Possible biological names infered from orthology : P02790
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 105591613
Gene end: 105600137
  
Corresponding Affymetrix probe sets: 10566477 (MoGene1.0st)   1423944_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147802
Ensembl peptide - ENSMUSP00000033185
NCBI entrez gene - 15458     See in Manteia.
MGI - MGI:105112
RefSeq - NM_017371
RefSeq Peptide - NP_059067
swissprot - A0A1B0GS57
swissprot - Q91X72
Ensembl - ENSMUSG00000030895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpxENSDARG00000012609Danio rerio
 zgc:152945ENSDARG00000051912Danio rerio
 HPXENSGALG00000022586Gallus gallus
 HPXENSG00000110169Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR016358  Hemopexin
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002639 positive regulation of immunoglobulin production IMP
 biological_processGO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0015886 heme transport IEA
 biological_processGO:0020027 hemoglobin metabolic process IMP
 biological_processGO:0042168 heme metabolic process IMP
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0051246 regulation of protein metabolic process IMP
 biological_processGO:0060332 positive regulation of response to interferon-gamma IMP
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0015232 heme transporter activity IEA
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Scavenging of heme from plasma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000315 hemoglobinuria "the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

 MP:0012666 increased circulating haptoglobin level 
Show

Allelic Composition: Casp3tm1Dsp/Casp3tm1Dsp
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029368 Alb / P07724 / Serum albumin / P02768* / albumin*  / reaction
 ENSMUSG00000073940 Hbb-bt / HBB* / HBD* / P68871* / P02042* / hemoglobin subunit beta* / hemoglobin subunit delta*  / reaction
 ENSMUSG00000030895 Hpx / Q91X72 / Hemopexin / P02790*  / reaction
 ENSMUSG00000069919 Hba-a1 / hemoglobin alpha, adult chain 1 / HBA2* / HBA1* / P69905* / hemoglobin subunit alpha 1* / hemoglobin subunit alpha 2*  / reaction






 

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