MP:0000188 | abnormal circulating glucose level | "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0000195 | hypocalcemia | "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan Genetic Background: Not Specified
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MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bub1tm3.1Jvd/Bub1tm3.1Jvd Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0001762 | polyuria | "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
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MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Map3k7tm1Mis/Map3k7tm1Mis,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: C57BL/6J * CBA/J
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MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hnf4atm1(cre)Sdv/Hnf4a+ Genetic Background: involves: 129S/SvEv * CD-1
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0002901 | hyperphosphaturia | "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+ Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
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MP:0002941 | increased circulating alanine transaminase level | "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Sqstm1tm1.1Sral/Sqstm1+ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0002988 | decreased urine osmolarity | "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
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MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0003324 | liver adenoma | "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0003868 | abnormal feces composition | "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
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MP:0003926 | impaired cellular glucose import | "reduced ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0004774 | abnormal bile salt level | "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0004789 | increased bile salt level | "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
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MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0005342 | abnormal lipid absorption | "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
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MP:0005419 | hypoalbuminemia | "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Map7Gt(ROSABetageo)1Sor/Map7Gt(ROSABetageo)1Sor Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Albem12Mvw/Albem12Mvw,Fcgrttm1Dcr/Fcgrttm1Dcr,Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr Genetic Background: B6.Cg-Albem12Mvw Fcgrttm1Dcr Tg(FCGRT)32Dcr/MvwJ
Allelic Composition: AlbMhdabcl002/Alb+ Genetic Background: C3HeB/FeJ-AlbMhdabcl002
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MP:0005438 | abnormal glycogen homeostasis | "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0005517 | decreased liver regeneration | "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cul3tm1Suc/Cul3+ Genetic Background: involves: C57BL/6
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MP:0005619 | increased potassium excretion | "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
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MP:0008738 | abnormal liver iron level | "anomaly in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0 Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn
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MP:0008821 | increased blood uric acid level | "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0009350 | decreased urine pH | "increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
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MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0009356 | decreased liver triglyceride level | "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0009642 | abnormal blood homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
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MP:0010026 | decreased liver cholesterol level | "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0010080 | abnormal hepatocyte physiology | "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sqstm1tm1.1Sral/Sqstm1+ Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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MP:0010297 | increased hepatobiliary system tumor incidence | |
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn
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MP:0010315 | increased cholangiocarcinoma incidence | "greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+,Trpv1tm1Jul/Trpv1tm1Jul,Tg(Mrgpra3-GFP/cre)#Xzd/0 Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ
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MP:0010400 | increased liver glycogen level | "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0011435 | increased urine magnesium level | "higher than normal amount of magnesium in the urine" [MGI:anna] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9+ Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
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MP:0011537 | uraturia | "passage of an increased amount of any salt or ester of uric acid (urate) in the urine" [MGI:anna] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Slc2a9tm1.1Thor/Slc2a9tm1.1Thor Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N
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MP:0011584 | increased alkaline phosphatase activity | "greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035] |
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Allelic Composition: AlbMhdabcl002/Alb+ Genetic Background: C3HeB/FeJ-AlbMhdabcl002
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MP:0030021 | increased muscle cell glucose uptake | "increased ability of muscle cells to take in glucose" [MGI:anna] |
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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