ENSMUSG00000035540


Mus musculus

Features
Gene ID: ENSMUSG00000035540
  
Biological name :Gc
  
Synonyms : Gc / P21614 / Vitamin D-binding protein
  
Possible biological names infered from orthology : GC, vitamin D binding protein / P02774
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E1
Gene start: 89417522
Gene end: 89457898
  
Corresponding Affymetrix probe sets: 10531149 (MoGene1.0st)   1426547_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143624
Ensembl peptide - ENSMUSP00000046636
NCBI entrez gene - 14473     See in Manteia.
MGI - MGI:95669
RefSeq - NM_008096
RefSeq Peptide - NP_032122
swissprot - A0A0G2JGM6
swissprot - P21614
Ensembl - ENSMUSG00000035540
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcENSDARG00000089310Danio rerio
 GCENSGALG00000011612Gallus gallus
 GCENSG00000145321Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alb / P07724 / Serum albumin / P02768* / albumin*ENSMUSG0000002936821
Afp / P02772 / Alpha-fetoprotein / P02771*ENSMUSG0000005493221
Afm / O89020 / Afamin / P43652*ENSMUSG0000002936918
5830473C10Rik / RIKEN cDNA 5830473C10 geneENSMUSG0000007069018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000213  Vitamin D-binding protein
 IPR000264  ALB/AFP/VDB
 IPR014760  Serum albumin, N-terminal
 IPR015247  Vitamin D binding protein, domain III
 IPR020857  Serum albumin, conserved site
 IPR020858  Serum albumin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035461 vitamin transmembrane transport IEA
 biological_processGO:0042359 vitamin D metabolic process IDA
 biological_processGO:0051180 vitamin transport IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0005499 vitamin D binding IEA
 molecular_functionGO:0090482 vitamin transmembrane transporter activity IEA
 molecular_functionGO:1902118 calcidiol binding IEA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003432 increased activity of parathyroid "increased function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026726 Cubn / Q9JLB4 / Cubilin / O60494*  / complex / reaction
 ENSMUSG00000027070 Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*  / reaction






 

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