ENSMUSG00000026726


Mus musculus

Features
Gene ID: ENSMUSG00000026726
  
Biological name :Cubn
  
Synonyms : Cubilin / Cubn / Q9JLB4
  
Possible biological names infered from orthology : O60494
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 13276338
Gene end: 13491813
  
Corresponding Affymetrix probe sets: 10480155 (MoGene1.0st)   1426990_at (Mouse Genome 430 2.0 Array)   1452270_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089009
NCBI entrez gene - 65969     See in Manteia.
MGI - MGI:1931256
RefSeq - NM_001081084
RefSeq Peptide - NP_001074553
swissprot - Q9JLB4
Ensembl - ENSMUSG00000026726
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cubnENSDARG00000087013Danio rerio
 CUBNENSGALG00000008704Gallus gallus
 CUBNENSG00000107611Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp1 / P98063 / Bone morphotic protein 1 / P13497* / bone morphogenetic protein 1*ENSMUSG000000220988
Tll2 / Q9WVM6 / Tolloid-like protein 2 / Q9Y6L7* / tolloid like 2*ENSMUSG000000250138
Tll1 / tolloid-like / O43897* / tolloid like 1*ENSMUSG000000536268
Mfrp / Q8K480 / Membrane frizzled-related protein / Q9BY79*ENSMUSG000000347394
Pcolce / Q61398 / Procollagen C-endopeptidase enhancer 1 / Q15113* / procollagen C-endopeptidase enhancer*ENSMUSG000000297184
Cdcp2 / Q8BQH6 / CUB domain-containing protein 2 / Q5VXM1*ENSMUSG000000476364
Q8R4W6 / Pcolce2 / Procollagen C-endopeptidase enhancer 2 / Q9UKZ9*ENSMUSG000000153543
Neto2 / Q8BNJ6 / Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcript variant 1, mRNA. / Q8NC67* / neuropilin and tolloid like 2*ENSMUSG000000369023
Neto1 / Q8R4I7 / Neuropilin and tolloid-like protein 1 / Q8TDF5* / neuropilin and tolloid like 1*ENSMUSG000000503213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006898 receptor-mediated endocytosis IMP
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0042953 lipoprotein transport IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005905 clathrin-coated pit IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031526 brush border membrane ISS
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding ISS
 molecular_functionGO:0031419 cobalamin binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cobalamin (Cbl, vitamin B12) transport and metabolism
Vitamin D (calciferol) metabolism
HDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Lrp2tm1Tew/Lrp2tm1Tew,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0011227 abnormal vitamin B12 level "any anomaly in the concentration of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom" [GO:0009236]
Show

Allelic Composition: Cubntm1Rkoz/Cubntm1Rkoz,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021278 Amn / Q99JB7 / Protein amnionless / Q9BXJ7* / amnion associated transmembrane protein*  / complex
 ENSMUSG00000032083 Apoa1 / Q00623 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647* / apolipoprotein A1*  / reaction / complex
 ENSMUSG00000035540 Gc / P21614 / Vitamin D-binding protein / P02774* / GC, vitamin D binding protein*  / complex / reaction
 ENSMUSG00000024682 Gif / P52787 / Gastric intrinsic factor / P27352*  / complex / reaction
 ENSMUSG00000027070 Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*  / reaction






 

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