ENSMUSG00000032083


Mus musculus

Features
Gene ID: ENSMUSG00000032083
  
Biological name :Apoa1
  
Synonyms : Apoa1 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / Q00623
  
Possible biological names infered from orthology : apolipoprotein A1 / P02647
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 46228580
Gene end: 46230466
  
Corresponding Affymetrix probe sets: 10585005 (MoGene1.0st)   1419232_a_at (Mouse Genome 430 2.0 Array)   1419233_x_at (Mouse Genome 430 2.0 Array)   1438840_x_at (Mouse Genome 430 2.0 Array)   1455201_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150525
Ensembl peptide - ENSMUSP00000034588
NCBI entrez gene - 11806     See in Manteia.
MGI - MGI:88049
RefSeq - NM_009692
RefSeq Peptide - NP_033822
swissprot - A0A1L1STX7
swissprot - Q00623
Ensembl - ENSMUSG00000032083
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apoa1aENSDARG00000012076Danio rerio
 apoa1bENSDARG00000101324Danio rerio
 APOA1ENSGALG00000007114Gallus gallus
 APOA1ENSG00000118137Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apoa5 / Q8C7G5 / Mus musculus apolipoprotein A-V (Apoa5), transcript variant 2, mRNA. / Q6Q788* / apolipoprotein A5*ENSMUSG0000003207920
Apoa4 / P06728 / Apolipoprotein A-IV / P06727* / apolipoprotein A4*ENSMUSG0000003208020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000074  Apolipoprotein A/E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IMP
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IMP
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process ISO
 biological_processGO:0008211 glucocorticoid metabolic process IMP
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0010873 positive regulation of cholesterol esterification IEA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process IBA
 biological_processGO:0010903 negative regulation of very-low-density lipoprotein particle remodeling IEA
 biological_processGO:0018158 protein oxidation IEA
 biological_processGO:0018206 peptidyl-methionine modification IEA
 biological_processGO:0019433 triglyceride catabolic process IBA
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IDA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0031102 neuron projection regeneration IBA
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IEA
 biological_processGO:0033344 cholesterol efflux IEA
 biological_processGO:0033700 phospholipid efflux IEA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IBA
 biological_processGO:0034375 high-density lipoprotein particle remodeling IEA
 biological_processGO:0034380 high-density lipoprotein particle assembly IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042158 lipoprotein biosynthetic process IMP
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 biological_processGO:0043691 reverse cholesterol transport IEA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IBA
 biological_processGO:0046470 phosphatidylcholine metabolic process IBA
 biological_processGO:0050713 negative regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IBA
 biological_processGO:0051180 vitamin transport IEA
 biological_processGO:0051345 positive regulation of hydrolase activity IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IGI
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0055091 phospholipid homeostasis IEA
 biological_processGO:0060354 negative regulation of cell adhesion molecule production IEA
 biological_processGO:0060761 negative regulation of response to cytokine stimulus IEA
 biological_processGO:0070328 triglyceride homeostasis IEA
 biological_processGO:0070508 cholesterol import IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IEA
 cellular_componentGO:0034364 high-density lipoprotein particle ISO
 cellular_componentGO:0034366 spherical high-density lipoprotein particle IEA
 cellular_componentGO:0042627 chylomicron IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005319 lipid transporter activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008035 high-density lipoprotein particle binding IDA
 molecular_functionGO:0008289 lipid binding IDA
 molecular_functionGO:0015485 cholesterol binding IEA
 molecular_functionGO:0017127 cholesterol transporter activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IBA
 molecular_functionGO:0034190 apolipoprotein receptor binding IEA
 molecular_functionGO:0034191 apolipoprotein A-I receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045499 chemorepellent activity IEA
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IEA
 molecular_functionGO:0070653 high-density lipoprotein particle receptor binding IEA
 molecular_functionGO:0071813 lipoprotein particle binding IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ABC transporters in lipid homeostasis
Scavenging of heme from plasma
Scavenging by Class B Receptors
Scavenging by Class A Receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Chylomicron assembly
HDL assembly
Chylomicron remodeling
HDL clearance
HDL remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoa1tm1Unc/Apoa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoa1tm1Bres/Apoa1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres,Apoa2tm1Bres/Apoa2tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres,Tg(Mt1-CETP)#Tall/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

Allelic Composition: Apoa1tm1(APOA1)Prli/Apoa1tm2(APOA1)Prli
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA1)1Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA2)3Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Tc/T
Genetic Background: Not Specified

 MP:0003191 abnormal cellular cholesterol metabolism "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0003192 increased cholesterol efflux "greater level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA1)1Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoa1tm1Bres/Apoa1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003692 xanthoma "a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0003981 decreased circulating phospholipid level "reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA1)1Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

Allelic Composition: Apoa1tm1(APOA1)Prli/Apoa1tm2(APOA1)Prli
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoa1tm1Unc/Apoa1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Apoa1tm1Unc/Apoa1+
Genetic Background: B6.129P2-Apoa1tm1Unc

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Tg(APOA2)3Rub/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
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Allelic Composition: Fbn2fp-2J/Fbn2fp-2J
Genetic Background: involves: C57BL/6J * C.B10-H2b/LiMcdJ

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

 MP:0010072 increased pruritus "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Apoa1tm1Unc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022098 Bmp1 / P98063 / Bone morphotic protein 1 / P13497* / bone morphogenetic protein 1*  / reaction
 ENSMUSG00000021278 Amn / Q99JB7 / Protein amnionless / Q9BXJ7* / amnion associated transmembrane protein*  / complex / reaction
 ENSMUSG00000032083 Apoa1 / Q00623 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647* / apolipoprotein A1*  / complex / reaction
 ENSMUSG00000026726 Cubn / Q9JLB4 / Cubilin / O60494*  / reaction / complex
 ENSMUSG00000015243 Abca1 / P41233 / ATP-binding cassette, sub-family A (ABC1), member 1 / O95477* / ATP binding cassette subfamily A member 1*  / reaction / complex
 ENSMUSG00000035722 Abca7 / Q91V24 / ATP-binding cassette, sub-family A (ABC1), member 7 / Q8IZY2* / ATP binding cassette subfamily A member 7*  / complex
 ENSMUSG00000035237 Lcat / P16301 / Phosphatidylcholine-sterol acyltransferase / P04180* / lecithin-cholesterol acyltransferase*  / reaction / complex






 

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