ENSMUSG00000032079


Mus musculus

Features
Gene ID: ENSMUSG00000032079
  
Biological name :Apoa5
  
Synonyms : Apoa5 / Mus musculus apolipoprotein A-V (Apoa5), transcript variant 2, mRNA. / Q8C7G5
  
Possible biological names infered from orthology : apolipoprotein A5 / Q6Q788
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 46268633
Gene end: 46271919
  
Corresponding Affymetrix probe sets: 10585015 (MoGene1.0st)   1417610_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113413
Ensembl peptide - ENSMUSP00000151068
Ensembl peptide - ENSMUSP00000149877
Ensembl peptide - ENSMUSP00000149834
Ensembl peptide - ENSMUSP00000149135
Ensembl peptide - ENSMUSP00000034584
NCBI entrez gene - 66113     See in Manteia.
MGI - MGI:1913363
RefSeq - XM_006510538
RefSeq - NM_001348095
RefSeq - NM_080434
RefSeq Peptide - NP_001335024
RefSeq Peptide - NP_536682
swissprot - A0A1L1SV61
swissprot - A0A1L1SSE5
swissprot - A0A1L1SQP3
swissprot - A0A1L1SSC4
swissprot - Q8C7G5
Ensembl - ENSMUSG00000032079
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apoa4aENSDARG00000101160Danio rerio
 apoa4b.1ENSDARG00000040298Danio rerio
 apoa4b.2ENSDARG00000094929Danio rerio
 apoa4b.2ENSDARG00000020866Danio rerio
 APOA5ENSGALG00000014368Gallus gallus
 APOA5ENSG00000110243Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apoa4 / P06728 / Apolipoprotein A-IV / P06727* / apolipoprotein A4*ENSMUSG0000003208019
Apoa1 / Q00623 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647* / apolipoprotein A1*ENSMUSG0000003208314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000074  Apolipoprotein A/E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006641 triglyceride metabolic process ISO
 biological_processGO:0006695 cholesterol biosynthetic process IBA
 biological_processGO:0006869 lipid transport ISO
 biological_processGO:0010873 positive regulation of cholesterol esterification IBA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process ISO
 biological_processGO:0010902 positive regulation of very-low-density lipoprotein particle remodeling ISO
 biological_processGO:0019433 triglyceride catabolic process IBA
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IBA
 biological_processGO:0031102 neuron projection regeneration IBA
 biological_processGO:0033344 cholesterol efflux IBA
 biological_processGO:0033700 phospholipid efflux IBA
 biological_processGO:0034370 triglyceride-rich lipoprotein particle remodeling IMP
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IBA
 biological_processGO:0034380 high-density lipoprotein particle assembly IBA
 biological_processGO:0042157 lipoprotein metabolic process IBA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0042632 cholesterol homeostasis IBA
 biological_processGO:0043691 reverse cholesterol transport IBA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process ISO
 biological_processGO:0046470 phosphatidylcholine metabolic process IBA
 biological_processGO:0050996 positive regulation of lipid catabolic process ISO
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity ISO
 biological_processGO:0055090 acylglycerol homeostasis IMP
 biological_processGO:0070328 triglyceride homeostasis ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0034361 very-low-density lipoprotein particle ISO
 cellular_componentGO:0034364 high-density lipoprotein particle ISO
 cellular_componentGO:0042627 chylomicron IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0005543 phospholipid binding ISO
 molecular_functionGO:0008047 enzyme activator activity ISO
 molecular_functionGO:0008201 heparin binding ISO
 molecular_functionGO:0008289 lipid binding ISO
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0017127 cholesterol transporter activity IBA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0031210 phosphatidylcholine binding IBA
 molecular_functionGO:0035473 lipase binding ISO
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISO
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IBA
 molecular_functionGO:0060229 lipase activator activity ISO
 molecular_functionGO:0060230 lipoprotein lipase activator activity ISO
 molecular_functionGO:0070325 lipoprotein particle receptor binding ISO


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Chylomicron remodeling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Kif1cLtxs1-DBA/2NCr/Kif1cLtxs1-DBA/2NCr,Ltxs2DBA/2NCr/Ltxs2DBA/2NCr,Ltxs3DBA/2NCr/Ltxs3DBA/2NCr
Genetic Background: involves: BALB/cAnPt * DBA/2NCr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoa5tm1Hgc/Apoa5+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kif1cLtxs1-DBA/2NCr/Kif1cLtxs1-DBA/2NCr,Ltxs2DBA/2NCr/Ltxs2DBA/2NCr,Ltxs3DBA/2NCr/Ltxs3DBA/2NCr
Genetic Background: involves: BALB/cAnPt * DBA/2NCr

Allelic Composition: Apoa5tm1Hgc/Apoa5+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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