ENSMUSG00000032080


Mus musculus

Features
Gene ID: ENSMUSG00000032080
  
Biological name :Apoa4
  
Synonyms : Apoa4 / Apolipoprotein A-IV / P06728
  
Possible biological names infered from orthology : apolipoprotein A4 / P06727
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 46240696
Gene end: 46243459
  
Corresponding Affymetrix probe sets: 10585010 (MoGene1.0st)   1417761_at (Mouse Genome 430 2.0 Array)   1436504_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034585
NCBI entrez gene - 11808     See in Manteia.
MGI - MGI:88051
RefSeq - NM_007468
RefSeq Peptide - NP_031494
swissprot - P06728
Ensembl - ENSMUSG00000032080
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apoa4aENSDARG00000101160Danio rerio
 apoa4b.1ENSDARG00000040298Danio rerio
 apoa4b.2ENSDARG00000094929Danio rerio
 apoa4b.2ENSDARG00000020866Danio rerio
 APOA4ENSGALG00000007109Gallus gallus
 APOA4ENSG00000110244Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apoa5 / Q8C7G5 / Mus musculus apolipoprotein A-V (Apoa5), transcript variant 2, mRNA. / Q6Q788* / apolipoprotein A5*ENSMUSG0000003207917
Apoa1 / Q00623 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647* / apolipoprotein A1*ENSMUSG0000003208314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000074  Apolipoprotein A/E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002227 innate immune response in mucosa IMP
 biological_processGO:0006695 cholesterol biosynthetic process IBA
 biological_processGO:0006869 lipid transport ISO
 biological_processGO:0006982 response to lipid hydroperoxide IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010873 positive regulation of cholesterol esterification IEA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0019433 triglyceride catabolic process IBA
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IMP
 biological_processGO:0031102 neuron projection regeneration IBA
 biological_processGO:0032374 regulation of cholesterol transport IEA
 biological_processGO:0033344 cholesterol efflux IEA
 biological_processGO:0033700 phospholipid efflux IEA
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IEA
 biological_processGO:0034380 high-density lipoprotein particle assembly IBA
 biological_processGO:0034445 negative regulation of plasma lipoprotein oxidation IEA
 biological_processGO:0035634 response to stilbenoid IEP
 biological_processGO:0042157 lipoprotein metabolic process IBA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0043691 reverse cholesterol transport IEA
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IEA
 biological_processGO:0046470 phosphatidylcholine metabolic process IEA
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IEA
 biological_processGO:0055088 lipid homeostasis IEA
 biological_processGO:0065005 protein-lipid complex assembly IEA
 biological_processGO:0070328 triglyceride homeostasis IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IEA
 cellular_componentGO:0034364 high-density lipoprotein particle ISO
 cellular_componentGO:0042627 chylomicron IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0008289 lipid binding ISO
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0017127 cholesterol transporter activity IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IEA


Pathways (from Reactome)
Pathway description
Chylomicron assembly
Chylomicron remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f4del-J/Pou3f4+
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Artm1Verh/Y,Rnase10tm1(cre)Hht/Rnase10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Artm1Verh/Y,Rnase10tm1(cre)Hht/Rnase10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4+
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4+
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Artm1Verh/Y,Rnase10tm1(cre)Hht/Rnase10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Artm1Verh/Y,Rnase10tm1(cre)Hht/Rnase10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f4del-J/Pou3f4+
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f4del-J/Pou3f4+
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Pou3f4del-J/Pou3f4+
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Artm1Verh/Y,Rnase10tm1(cre)Hht/Rnase10+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zap70m1Saka/Zap70tm1Dlo,Tg(Lck-ZAP70)824Saka/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Pou3f4del-J/Pou3f4+
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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