ENSG00000110244


Homo sapiens

Features
Gene ID: ENSG00000110244
  
Biological name :APOA4
  
Synonyms : APOA4 / apolipoprotein A4 / P06727
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q23.3
Gene start: 116820700
Gene end: 116823306
  
Corresponding Affymetrix probe sets: 206894_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000350425
NCBI entrez gene - 337     See in Manteia.
OMIM - 107690
RefSeq - NM_000482
RefSeq Peptide - NP_000473
swissprot - P06727
Ensembl - ENSG00000110244
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apoa4aENSDARG00000101160Danio rerio
 apoa4b.1ENSDARG00000040298Danio rerio
 apoa4b.2ENSDARG00000094929Danio rerio
 apoa4b.2ENSDARG00000020866Danio rerio
 APOA4ENSGALG00000007109Gallus gallus
 Apoa4ENSMUSG00000032080Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APOA5 / Q6Q788 / apolipoprotein A5ENSG0000011024322
APOA1 / P02647 / apolipoprotein A1ENSG0000011813716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000074  Apolipoprotein A/E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0002227 innate immune response in mucosa IDA
 biological_processGO:0006695 cholesterol biosynthetic process IBA
 biological_processGO:0006869 lipid transport IDA
 biological_processGO:0006982 response to lipid hydroperoxide IDA
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0008203 cholesterol metabolic process IDA
 biological_processGO:0010873 positive regulation of cholesterol esterification IDA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process IDA
 biological_processGO:0019430 removal of superoxide radicals IDA
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IEA
 biological_processGO:0031102 neuron projection regeneration IBA
 biological_processGO:0032374 regulation of cholesterol transport IDA
 biological_processGO:0033344 cholesterol efflux IDA
 biological_processGO:0033700 phospholipid efflux IDA
 biological_processGO:0034371 chylomicron remodeling IC
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IDA
 biological_processGO:0034375 high-density lipoprotein particle remodeling IC
 biological_processGO:0034378 chylomicron assembly TAS
 biological_processGO:0034380 high-density lipoprotein particle assembly IBA
 biological_processGO:0034445 negative regulation of plasma lipoprotein oxidation IDA
 biological_processGO:0035634 response to stilbenoid IEA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IDA
 biological_processGO:0042744 hydrogen peroxide catabolic process IDA
 biological_processGO:0043691 reverse cholesterol transport IDA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IDA
 biological_processGO:0046470 phosphatidylcholine metabolic process IDA
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IDA
 biological_processGO:0055088 lipid homeostasis IDA
 biological_processGO:0065005 protein-lipid complex assembly IMP
 biological_processGO:0070328 triglyceride homeostasis IBA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IDA
 cellular_componentGO:0034364 high-density lipoprotein particle IDA
 cellular_componentGO:0042627 chylomicron IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0005319 lipid transporter activity TAS
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IMP
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0016209 antioxidant activity IDA
 molecular_functionGO:0017127 cholesterol transporter activity IDA
 molecular_functionGO:0031210 phosphatidylcholine binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IDA


Pathways (from Reactome)
Pathway description
Chylomicron assembly
Assembly of active LPL and LIPC lipase complexes
Chylomicron remodeling
Retinoid metabolism and transport
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110244 APOA4 / P06727 / apolipoprotein A4  / -






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr