MP:0000183 | decreased circulating LDL cholesterol level | "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcat+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0000639 | abnormal adrenal gland morphology | "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190] |
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs Genetic Background: B6.129-Tnfsf10tm1Mjs
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MP:0001547 | abnormal lipid level | "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcat+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: C57BL/6 * DBA
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MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcat+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
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MP:0001585 | hemolytic anemia | "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
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MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tnfsf10tm1Mjs/Tnfsf10tm1Mjs Genetic Background: B6.129-Tnfsf10tm1Mjs
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0002640 | reticulocytosis | "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
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MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0002703 | abnormal renal tubules | "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
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MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
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MP:0003657 | abnormal erythrocyte lysis | "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
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MP:0003980 | increased circulating phospholipid level | "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0003982 | increased cholesterol level | "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: C57BL/6 * DBA
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MP:0003983 | decreased cholesterol level | "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: C57BL/6 * DBA
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MP:0004756 | abnormal proximal convoluted tubule morphology | "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0005145 | increased circulating VLDL cholesterol level | "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0005146 | decreased circulating VLDL cholesterol level | "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
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MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcat+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcat+ Genetic Background: involves: C57BL/6 * DBA
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MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0005278 | abnormal cholesterol homeostasis | "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350] |
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Allelic Composition: GnaqMhdadsk1/GnaqMhdadsk1 Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Lcattm1Nsa/Lcat+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
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MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0005326 | abnormal podocytes | "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0005416 | abnormal circulating protein level | "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcat+ Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
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MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
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MP:0006084 | abnormal circulating phospholipid level | "anomalous concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
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MP:0008140 | podocyte foot process effacement | "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0011312 | abnormal kidney afferent arteriole morphology | "any structural anomaly of the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
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MP:0011320 | abnormal glomerular capillary morphology | "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0011353 | expanded mesangial matrix | "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0011427 | mesangial cell hyperplasia | "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna] |
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Allelic Composition: Lcattm1Nsa/Lcattm1Nsa Genetic Background: B6.Cg-Lcattm1Nsa
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Tg(SREBP1a)7343Reh/? Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Lcattm1Hgc/Lcattm1Hgc Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL
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MP:0011579 | decreased lipoprotein lipase activity | "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465] |
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Allelic Composition: Lcattm1Hgc/Lcattm1Hgc,Ldlrtm1Her/Ldlrtm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
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