ENSMUSG00000031903


Mus musculus

Features
Gene ID: ENSMUSG00000031903
  
Biological name :Pla2g15
  
Synonyms : Mus musculus phospholipase A2, group XV (Pla2g15), transcript variant 2, mRNA. / Pla2g15 / Q8VEB4
  
Possible biological names infered from orthology : phospholipase A2 group XV / Q8NCC3
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 106150399
Gene end: 106164715
  
Corresponding Affymetrix probe sets: 10574976 (MoGene1.0st)   1422341_s_at (Mouse Genome 430 2.0 Array)   1423704_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034377
Ensembl peptide - ENSMUSP00000148565
NCBI entrez gene - 192654     See in Manteia.
MGI - MGI:2178076
RefSeq - XM_006530772
RefSeq - NM_001357319
RefSeq - NM_133792
RefSeq Peptide - NP_001344248
RefSeq Peptide - NP_598553
swissprot - Q8VEB4
swissprot - A0A1D5RLZ5
Ensembl - ENSMUSG00000031903
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g15ENSDARG00000103271Danio rerio
 PLA2G15ENSGALG00000041787Gallus gallus
 Q8NCC3ENSG00000103066Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lcat / P16301 / Phosphatidylcholine-sterol acyltransferase / P04180* / lecithin-cholesterol acyltransferase*ENSMUSG0000003523746


Protein motifs (from Interpro)
Interpro ID Name
 IPR003386  Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006650 glycerophospholipid metabolic process IEA
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0034638 phosphatidylcholine catabolic process IMP
 biological_processGO:0046338 phosphatidylethanolamine catabolic process IMP
 biological_processGO:0046470 phosphatidylcholine metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0008374 O-acyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047499 calcium-independent phospholipase A2 activity IEA


Pathways (from Reactome)
Pathway description
Hydrolysis of LPC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plgtm1Jld/Plg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Plgtm1Jld/Plg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plgtm1Jld/Plg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plgtm1Jld/Plg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plgtm1Jld/Plg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Pla2g15tm1.1Jash/Pla2g15tm1.1Jash
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plgtm1Jld/Plg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pla2g15tm1.1Jash/Pla2g15tm1.1Jash
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004778 increased foam cell number "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
Show

Allelic Composition: Pla2g15tm1.1Jash/Pla2g15tm1.1Jash
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pla2g15tm1.1Jash/Pla2g15tm1.1Jash
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pla2g15tm1Ytan/Pla2g15tm1Ytan
Genetic Background: involves: 129S/SvEv * B6.129P2-Apoetm1Unc/J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpztm1Msch/Mpz+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Pla2g15tm1.1Jash/Pla2g15tm1.1Jash
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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