ENSGALG00000007114


Gallus gallus

Features
Gene ID: ENSGALG00000007114
  
Biological name :APOA1
  
Synonyms : APOA1 / Apolipoprotein A-I Proapolipoprotein A-I / P08250
  
Possible biological names infered from orthology : apolipoprotein A1 / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I / P02647 / Q00623
  
Species: Gallus gallus
  
Chr. number: 24
Strand: -1
Band:
Gene start: 5110448
Gene end: 5112102
  
Corresponding Affymetrix probe sets: Gga.4719.1.S1_a_at (Chicken Array)   Gga.4719.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000056904
Ensembl peptide - ENSGALP00000064466
Ensembl peptide - ENSGALP00000062655
Ensembl peptide - ENSGALP00000058880
Ensembl peptide - ENSGALP00000058786
Ensembl peptide - ENSGALP00000058354
Ensembl peptide - ENSGALP00000011510
NCBI entrez gene - 396536     See in Manteia.
RefSeq - NM_205525
RefSeq - XM_015297971
RefSeq Peptide - NP_990856
swissprot - A0A1D5PZE3
swissprot - A0A1L1RV08
swissprot - P08250
swissprot - A0A1D5PVD8
swissprot - A0A1L1RJF5
swissprot - A0A1L1RJ60
Ensembl - ENSGALG00000007114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apoa1aENSDARG00000012076Danio rerio
 apoa1bENSDARG00000101324Danio rerio
 APOA1ENSG00000118137Homo sapiens
 Apoa1ENSMUSG00000032083Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APOA5 / apolipoprotein A5 / Q6Q788* / Q8C7G5* / Mus musculus apolipoprotein A-V (Apoa5), transcript variant 2, mRNA.*ENSGALG0000001436820
APOA4 / apolipoprotein A4 / P06727* / P06728* / Apolipoprotein A-IV *ENSGALG0000000710919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000074  Apolipoprotein A/E


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IBA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008211 glucocorticoid metabolic process IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0010873 positive regulation of cholesterol esterification IBA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process IBA
 biological_processGO:0010903 negative regulation of very-low-density lipoprotein particle remodeling IEA
 biological_processGO:0018158 protein oxidation IEA
 biological_processGO:0018206 peptidyl-methionine modification IEA
 biological_processGO:0019433 triglyceride catabolic process IBA
 biological_processGO:0019915 lipid storage IEA
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IBA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0031102 neuron projection regeneration IBA
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction IEA
 biological_processGO:0033344 cholesterol efflux IBA
 biological_processGO:0033700 phospholipid efflux IBA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IBA
 biological_processGO:0034375 high-density lipoprotein particle remodeling IEA
 biological_processGO:0034380 high-density lipoprotein particle assembly IBA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042158 lipoprotein biosynthetic process IEA
 biological_processGO:0042632 cholesterol homeostasis IBA
 biological_processGO:0043534 blood vessel endothelial cell migration IEA
 biological_processGO:0043691 reverse cholesterol transport IBA
 biological_processGO:0045445 myoblast differentiation TAS
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process IBA
 biological_processGO:0046470 phosphatidylcholine metabolic process IBA
 biological_processGO:0050713 negative regulation of interleukin-1 beta secretion IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IBA
 biological_processGO:0051180 vitamin transport IEA
 biological_processGO:0051345 positive regulation of hydrolase activity IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0055091 phospholipid homeostasis IEA
 biological_processGO:0060354 negative regulation of cell adhesion molecule production IEA
 biological_processGO:0060761 negative regulation of response to cytokine stimulus IEA
 biological_processGO:0070328 triglyceride homeostasis IBA
 biological_processGO:0070508 cholesterol import IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1901247 negative regulation of lung ciliated cell differentiation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IEA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 cellular_componentGO:0034366 spherical high-density lipoprotein particle IEA
 cellular_componentGO:0042627 chylomicron IBA
 cellular_componentGO:0072562 blood microparticle IBA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005319 lipid transporter activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008035 high-density lipoprotein particle binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IBA
 molecular_functionGO:0017127 cholesterol transporter activity IBA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031210 phosphatidylcholine binding IBA
 molecular_functionGO:0034190 apolipoprotein receptor binding IEA
 molecular_functionGO:0034191 apolipoprotein A-I receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045499 chemorepellent activity IEA
 molecular_functionGO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity IBA
 molecular_functionGO:0070653 high-density lipoprotein particle receptor binding IBA
 molecular_functionGO:0071813 lipoprotein particle binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ABC transporters in lipid homeostasis
Scavenging by Class B Receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Chylomicron assembly
HDL assembly
HDL clearance
HDL remodeling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008704 CUBN / cubilin / O60494* / Q9JLB4*  / complex / reaction
 ENSGALG00000007114 APOA1 / P08250 / Apolipoprotein A-I Proapolipoprotein A-I / P02647* / Q00623* / apolipoprotein A1* / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I*  / reaction / complex
 ENSGALG00000028928 LCAT / lecithin-cholesterol acyltransferase / P04180* / P16301* / Phosphatidylcholine-sterol acyltransferase *  / reaction / complex






 

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