ENSGALG00000008704


Gallus gallus

Features
Gene ID: ENSGALG00000008704
  
Biological name :CUBN
  
Synonyms : cubilin / CUBN
  
Possible biological names infered from orthology : O60494 / Q9JLB4
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 19883398
Gene end: 20025167
  
Corresponding Affymetrix probe sets: Gga.11199.1.S1_at (Chicken Array)   Gga.11199.1.S1_s_at (Chicken Array)   Gga.14579.1.S1_at (Chicken Array)   GgaAffx.22672.1.S1_at (Chicken Array)   GgaAffx.22672.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014150
Ensembl peptide - ENSGALP00000057946
Ensembl peptide - ENSGALP00000051975
NCBI entrez gene - 420523     See in Manteia.
RefSeq - XM_001235155
RefSeq - XM_015281998
swissprot - A0A1D5PY97
swissprot - A0A1D5PGQ2
swissprot - F1NIW7
Ensembl - ENSGALG00000008704
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cubnENSDARG00000087013Danio rerio
 CUBNENSG00000107611Homo sapiens
 CubnENSMUSG00000026726Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLL1 / tolloid-like protein 1 precursor / O43897* / tolloid-like* / tolloid like 1*ENSGALG000000095678
TLL2 / tolloid like 2 / Q9WVM6* / Q9Y6L7* / Tolloid-like protein 2 *ENSGALG000000055198
NETO2 / neuropilin and tolloid like 2 / Q8BNJ6* / Q8NC67* / Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcript variant 1, mRNA.*ENSGALG000000040714
CDCP2 / CUB domain containing protein 2 / Q5VXM1* / Q8BQH6*ENSGALG000000107524
PCOLCE2 / procollagen C-endopeptidase enhancer 2 / Q8R4W6* / Q9UKZ9*ENSGALG000000026233
MFRP / membrane frizzled-related protein / Q8K480* / Q9BY79*ENSGALG000000329792
NETO1 / neuropilin and tolloid like 1 / Q8R4I7* / Q8TDF5* / Neuropilin and tolloid-like protein 1 *ENSGALG000000411842


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0042953 lipoprotein transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Cobalamin (Cbl, vitamin B12) transport and metabolism
Vitamin D (calciferol) metabolism
HDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007114 APOA1 / P08250 / Apolipoprotein A-I Proapolipoprotein A-I / P02647* / Q00623* / apolipoprotein A1* / Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I*  / complex / reaction
 ENSGALG00000010858 LRP2 / LDL receptor related protein 2 / A2ARV4* / P98164* / low density lipoprotein receptor-related protein 2*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr