ENSGALG00000005519


Gallus gallus

Features
Gene ID: ENSGALG00000005519
  
Biological name :TLL2
  
Synonyms : TLL2 / tolloid like 2
  
Possible biological names infered from orthology : Q9WVM6 / Q9Y6L7 / Tolloid-like protein 2
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 16594013
Gene end: 16673810
  
Corresponding Affymetrix probe sets: GgaAffx.26520.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000008841
Ensembl peptide - ENSGALP00000048539
NCBI entrez gene - 107053676     See in Manteia.
RefSeq - XM_015288521
swissprot - A0A1D5P755
swissprot - F1NRI8
Ensembl - ENSGALG00000005519
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLL2ENSG00000095587Homo sapiens
 Tll2ENSMUSG00000025013Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLL1 / tolloid-like protein 1 precursor / O43897* / tolloid-like* / tolloid like 1*ENSGALG0000000956766
CUBN / cubilin / O60494* / Q9JLB4*ENSGALG0000000870425
CDCP2 / CUB domain containing protein 2 / Q5VXM1* / Q8BQH6*ENSGALG0000001075212
NETO2 / neuropilin and tolloid like 2 / Q8BNJ6* / Q8NC67* / Mus musculus neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2), transcript variant 1, mRNA.*ENSGALG0000000407110
PCOLCE2 / procollagen C-endopeptidase enhancer 2 / Q8R4W6* / Q9UKZ9*ENSGALG0000000262310
NETO1 / neuropilin and tolloid like 1 / Q8R4I7* / Q8TDF5* / Neuropilin and tolloid-like protein 1 *ENSGALG000000411847
MFRP / membrane frizzled-related protein / Q8K480* / Q9BY79*ENSGALG000000329796


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001506  Peptidase M12A
 IPR001881  EGF-like calcium-binding domain
 IPR006026  Peptidase, metallopeptidase
 IPR013032  EGF-like, conserved site
 IPR015446  Bone morphogenetic protein 1/tolloid-like protein
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0048632 negative regulation of skeletal muscle tissue growth IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Collagen biosynthesis and modifying enzymes
Anchoring fibril formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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