ENSG00000095587


Homo sapiens

Features
Gene ID: ENSG00000095587
  
Biological name :TLL2
  
Synonyms : Q9Y6L7 / TLL2 / tolloid like 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.1
Gene start: 96364606
Gene end: 96513918
  
Corresponding Affymetrix probe sets: 208027_s_at (Human Genome U133 Plus 2.0 Array)   215008_at (Human Genome U133 Plus 2.0 Array)   215843_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000350630
NCBI entrez gene - 7093     See in Manteia.
OMIM - 606743
RefSeq - NM_012465
RefSeq Peptide - NP_036597
swissprot - Q9Y6L7
Ensembl - ENSG00000095587
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLL2ENSGALG00000005519Gallus gallus
 Tll2ENSMUSG00000025013Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP1 / P13497 / bone morphogenetic protein 1ENSG0000016848773
TLL1 / O43897 / tolloid like 1ENSG0000003829572
CUBN / O60494 / cubilinENSG0000010761129
CDCP2 / Q5VXM1 / CUB domain containing protein 2ENSG0000015721113
MFRP / Q9BY79 / membrane frizzled-related proteinENSG0000023571813
NETO2 / Q8NC67 / neuropilin and tolloid like 2ENSG0000017120811
NETO1 / Q8TDF5 / neuropilin and tolloid like 1ENSG0000016634211
Q9UKZ9 / PCOLCE2 / procollagen C-endopeptidase enhancer 2ENSG0000016371011
PCOLCE / Q15113 / procollagen C-endopeptidase enhancerENSG0000010633310


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001506  Peptidase M12A
 IPR001881  EGF-like calcium-binding domain
 IPR006026  Peptidase, metallopeptidase
 IPR013032  EGF-like, conserved site
 IPR015446  Bone morphogenetic protein 1/tolloid-like protein
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034036  Tolloid/BMP1 peptidase domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048632 negative regulation of skeletal muscle tissue growth IEA
 cellular_componentGO:0005576 extracellular region TAS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Collagen biosynthesis and modifying enzymes
Anchoring fibril formation
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106333 PCOLCE / Q15113 / procollagen C-endopeptidase enhancer  / complex
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / reaction






 

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