ENSG00000106333


Homo sapiens

Features
Gene ID: ENSG00000106333
  
Biological name :PCOLCE
  
Synonyms : PCOLCE / procollagen C-endopeptidase enhancer / Q15113
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q22.1
Gene start: 100602177
Gene end: 100608175
  
Corresponding Affymetrix probe sets: 202465_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000223061
NCBI entrez gene - 5118     See in Manteia.
OMIM - 600270
RefSeq - NM_002593
RefSeq Peptide - NP_002584
swissprot - Q15113
Ensembl - ENSG00000106333
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcolceaENSDARG00000056913Danio rerio
 pcolcebENSDARG00000052057Danio rerio
 PcolceENSMUSG00000029718Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UKZ9 / PCOLCE2 / procollagen C-endopeptidase enhancer 2ENSG0000016371042
CUBN / O60494 / cubilinENSG0000010761132
BMP1 / P13497 / bone morphogenetic protein 1ENSG0000016848726
CDCP2 / Q5VXM1 / CUB domain containing protein 2ENSG0000015721125
TLL2 / Q9Y6L7 / tolloid like 2ENSG0000009558724
TLL1 / O43897 / tolloid like 1ENSG0000003829524
MFRP / Q9BY79 / membrane frizzled-related proteinENSG0000023571821
NETO2 / Q8NC67 / neuropilin and tolloid like 2ENSG0000017120816
NETO1 / Q8TDF5 / neuropilin and tolloid like 1ENSG0000016634215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000859  CUB domain
 IPR001134  Netrin domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR018933  Netrin module, non-TIMP type
 IPR028870  Procollagen C-endopeptidase enhancer 1
 IPR035814  Procollagen C-endopeptidase enhancer, NTR domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IDA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0016504 peptidase activator activity IDA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000095587 TLL2 / Q9Y6L7 / tolloid like 2  / complex






 

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